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Regional and cell-type-specific afferent and efferent projections of the mouse claustrum. 2023
Quanxin Wang, and
Yun Wang, and
Hsien-Chi Kuo, and
Peng Xie, and
Xiuli Kuang, and
Karla E Hirokawa, and
Maitham Naeemi, and
Shenqin Yao, and
Matt Mallory, and
Ben Ouellette, and
Phil Lesnar, and
Yaoyao Li, and
Min Ye, and
Chao Chen, and
Wei Xiong, and
Leila Ahmadinia, and
Laila El-Hifnawi, and
Ali Cetin, and
Staci A Sorensen, and
Julie A Harris, and
Hongkui Zeng, and
Christof Koch
Allen Institute for Brain Science, Seattle, WA 98109, USA. Electronic address: quanxinw@alleninstitute.org.
The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and subcortical regions. Its regional anatomy and cell-type-specific connections in the mouse remain not fully determined. Using multimodal reference datasets, we confirmed the delineation of the mouse CLA as a single group of neurons embedded in the agranular insular cortex. We quantitatively investigated brain-wide inputs and outputs of CLA using bulk anterograde and retrograde viral tracing data and single neuron tracing data. We found that the prefrontal module has more cell types projecting to the CLA than other cortical modules, with layer 5 IT neurons predominating. We found nine morphological types of CLA principal neurons that topographically innervate functionally linked cortical targets, preferentially the midline cortical areas, secondary motor area, and entorhinal area. Together, this study provides a detailed wiring diagram of the cell-type-specific connections of the mouse CLA, laying a foundation for studying its functions at the cellular level.
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