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[Waldenström macroglobulinemia complicated by peripheral neuropathy due to neural infiltration]. 2023
Natsuki Norioka, and
Naoki Kurita, and
Yuya Kamura, and
Tatsuhiro Sakamoto, and
Takayasu Kato, and
Yasuhisa Yokoyama, and
Hidekazu Nishikii, and
Naoshi Obara, and
Mamiko Sakata-Yanagimoto, and
Hana Takahashi, and
Kiyotaka Nakamagoe, and
Akiko Ishii, and
Ryota Matsuoka, and
Toru Nanmoku, and
Akira Tamaoka, and
Shigeru Chiba
Department of Hematology, University of Tsukuba Hospital.
A 51-year-old man with the chief complaint of glove- and stocking-type dysesthesia for >3 years was diagnosed with Waldenström's macroglobulinemia (WM) based on IgM-type M-proteinemia, bone marrow infiltration of plasmacytoid B cells, multiple lymphadenopathies, and splenomegaly. A nerve conduction examination suggested demyelinating neuropathy. Serum anti-myelin-associated glycoprotein antibody was negative. Sural nerve biopsy showed myelin thinning, suggesting demyelination. Axonal damage and tumor cell infiltration in the intrafascicular epineurium were also observed. After chemotherapies with rituximab and bendamustine, M-proteinemia and lymphadenopathies disappeared. However, abnormalities in the nerve conduction examination and dysesthesia were only slightly alleviated. As articles describing patients with WM with peripheral nerve infiltration are limited, we report this case with a literature review.
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