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It has been proposed that corticosteroids may be effective in the treatment of shock and the adult respiratory distress syndrome (ARDS) by inhibiting complement-induced granulocyte aggregation and by disaggregating granulocyte aggregates in vitro. In the present investigation we have examined the effects of sera from patients who had received comparable doses of methylprednisolone (MP) and dexamethasone (DEX) on the adherence of polymorphonuclear leukocytes (PMNs). Sera obtained from patients that had received MP markedly reduced PMN adherence with maximum effect noted by 8 h. In contrast, sera from patients receiving DEX had no effect on PMN adherence. The results of this study indicate that MP may be more effective in the treatment of septic shock and other conditions associated with microvascular leukostasis.
H P Bassaris, and
P E Lianou, and
K N Mallioris, and
A T Skoutelis, and
E G Votta, and
V E Kyriazopoulou, and
J T Papavassiliou
August 1981,
Infection and immunity,
H P Bassaris, and
P E Lianou, and
K N Mallioris, and
A T Skoutelis, and
E G Votta, and
V E Kyriazopoulou, and
J T Papavassiliou
May 1985,
Antimicrobial agents and chemotherapy,
H P Bassaris, and
P E Lianou, and
K N Mallioris, and
A T Skoutelis, and
E G Votta, and
V E Kyriazopoulou, and
J T Papavassiliou
April 2009,
Pediatric research,
H P Bassaris, and
P E Lianou, and
K N Mallioris, and
A T Skoutelis, and
E G Votta, and
V E Kyriazopoulou, and
J T Papavassiliou
January 1992,
Clinical therapeutics,
H P Bassaris, and
P E Lianou, and
K N Mallioris, and
A T Skoutelis, and
E G Votta, and
V E Kyriazopoulou, and
J T Papavassiliou
January 1984,
Advances in experimental medicine and biology,
H P Bassaris, and
P E Lianou, and
K N Mallioris, and
A T Skoutelis, and
E G Votta, and
V E Kyriazopoulou, and
J T Papavassiliou
January 1985,
International archives of allergy and applied immunology,
H P Bassaris, and
P E Lianou, and
K N Mallioris, and
A T Skoutelis, and
E G Votta, and
V E Kyriazopoulou, and
J T Papavassiliou
May 1980,
The Journal of laboratory and clinical medicine,
H P Bassaris, and
P E Lianou, and
K N Mallioris, and
A T Skoutelis, and
E G Votta, and
V E Kyriazopoulou, and
J T Papavassiliou
January 1985,
International journal of immunopharmacology,
H P Bassaris, and
P E Lianou, and
K N Mallioris, and
A T Skoutelis, and
E G Votta, and
V E Kyriazopoulou, and
J T Papavassiliou
April 1993,
Oral microbiology and immunology,
H P Bassaris, and
P E Lianou, and
K N Mallioris, and
A T Skoutelis, and
E G Votta, and
V E Kyriazopoulou, and
J T Papavassiliou
January 1986,
International archives of allergy and applied immunology,
