Biomaterial Database

A comparative study of the mutagenic activation of carcinogenic N-nitrosopropylamines by various animal species and man. 1987

Y Mori, and H Yamazaki, and Y Konishi

Laboratory of Radiochemistry, Gifu Pharmaceutical University, Japan.

N-Nitrosomethyl(2-hydroxypropyl)amine (NMHPA), N-nitrosomethyl(2-oxopropyl)-amine (NMOPA), N-nitrosomethyl(2,3-dihydroxypropyl)amine (NMD23HPA), N-nitrosobis(2-hydroxypropyl)amine (NDHPA), N-nitroso(2,3-dihydroxypropyl)(2-hydroxypropyl)-amine(ND23HPHPA), N-nitrosobis(2-acetoxypropyl)amine (NDAcPA) and N-nitroso-2,6-dimethylmorpholine (NDMMOR) were mutagenic in Salmonella typhimurium strain TA100 in the presence of liver 9000 X g supernatant (S9) from mice, rats, hamsters, rabbits and monkeys. N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine (NHPOPA) and N-nitrosobis(2-oxopropyl)amine (NDOPA) were mutagenic in strain TA100 without metabolic activation, and both compounds were further activated by animal liver S9. NMOPA and NMHPA were also mutagenic in the presence of lung S9 from these animals and in the presence of human lung or liver S9. Pancreatic S9 from any of the animals did not activate any of the nine N-nitrosamines to mutagens.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D009152	Mutagenicity Tests	Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.	Genetic Toxicity Tests,Genotoxicity Tests,Mutagen Screening,Tests, Genetic Toxicity,Toxicity Tests, Genetic,Genetic Toxicity Test,Genotoxicity Test,Mutagen Screenings,Mutagenicity Test,Screening, Mutagen,Screenings, Mutagen,Test, Genotoxicity,Tests, Genotoxicity,Toxicity Test, Genetic
D009602	Nitrosamines	A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.	Nitrosamine
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species