Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint. 2023

Shikha Kushwah, and Neha Shree Maurya, and Sandeep Kushwaha, and Luciana Scotti, and Aakash Chawade, and Ashutosh Mani
Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, 211004, India.

Alzheimer's is a chronic neurodegenerative disease where amyloid-beta (Aβ) plaques and neurofibrillary tangles are formed inside the brain. It is also characterized by progressive memory loss, depression, neuroinflammation, and derangement of other neurotransmitters. Due to its complex etiopathology, current drugs have failed to completely cure the disease. Natural compounds have been investigated as an alternative therapy for their ability to treat Alzheimer's disease (AD). Traditional herbs and formulations which are used in the Indian ayurvedic system are rich sources of antioxidant, anti-amyloidogenic, neuroprotective, and anti-inflammatory compounds. They promote quality of life by improving cognitive memory and rejuvenating brain functioning through neurogenesis. A rich knowledge base of traditional herbal plants (Turmeric, Gingko, Ashwagandha, Shankhpushpi, Giloy, Gotu kola, Garlic, Tulsi, Ginger, and Cinnamon) combined with modern science could suggest new functional leads for Alzheimer's drug discovery. In this article Ayurveda, the ancient Indian herbal medicine system based on multiple clinical and experimental, evidence have been reviewed for treating AD and improving brain functioning. This article presents a modern perspective on the herbs available in the ancient Indian medicine system as well as their possible mechanisms of action for AD treatment. The main objective of this research is to provide a systematic review of herbal drugs that are easily accessible and effective for the treatment of AD.

UI MeSH Term Description Entries
D008517 Phytotherapy Use of plants or herbs to treat diseases or to alleviate pain. Herb Therapy,Herbal Therapy
D011788 Quality of Life A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral, social environment as well as health and disease. HRQOL,Health-Related Quality Of Life,Life Quality,Health Related Quality Of Life
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000544 Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) Acute Confusional Senile Dementia,Alzheimer's Diseases,Dementia, Alzheimer Type,Dementia, Senile,Presenile Alzheimer Dementia,Senile Dementia, Alzheimer Type,Alzheimer Dementia,Alzheimer Disease, Early Onset,Alzheimer Disease, Late Onset,Alzheimer Sclerosis,Alzheimer Syndrome,Alzheimer Type Senile Dementia,Alzheimer's Disease,Alzheimer's Disease, Focal Onset,Alzheimer-Type Dementia (ATD),Dementia, Presenile,Dementia, Primary Senile Degenerative,Early Onset Alzheimer Disease,Familial Alzheimer Disease (FAD),Focal Onset Alzheimer's Disease,Late Onset Alzheimer Disease,Primary Senile Degenerative Dementia,Senile Dementia, Acute Confusional,Alzheimer Dementias,Alzheimer Disease, Familial (FAD),Alzheimer Diseases,Alzheimer Type Dementia,Alzheimer Type Dementia (ATD),Alzheimers Diseases,Dementia, Alzheimer,Dementia, Alzheimer-Type (ATD),Familial Alzheimer Diseases (FAD),Presenile Dementia,Sclerosis, Alzheimer,Senile Dementia
D019636 Neurodegenerative Diseases Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures. Degenerative Diseases, Nervous System,Degenerative Diseases, Central Nervous System,Degenerative Diseases, Neurologic,Degenerative Diseases, Spinal Cord,Degenerative Neurologic Diseases,Degenerative Neurologic Disorders,Nervous System Degenerative Diseases,Neurodegenerative Disorders,Neurologic Degenerative Conditions,Neurologic Degenerative Diseases,Neurologic Diseases, Degenerative,Degenerative Condition, Neurologic,Degenerative Conditions, Neurologic,Degenerative Neurologic Disease,Degenerative Neurologic Disorder,Neurodegenerative Disease,Neurodegenerative Disorder,Neurologic Degenerative Condition,Neurologic Degenerative Disease,Neurologic Disease, Degenerative,Neurologic Disorder, Degenerative,Neurologic Disorders, Degenerative

Related Publications

Shikha Kushwah, and Neha Shree Maurya, and Sandeep Kushwaha, and Luciana Scotti, and Aakash Chawade, and Ashutosh Mani
March 2000, The Journal of the Association of Physicians of India,
Shikha Kushwah, and Neha Shree Maurya, and Sandeep Kushwaha, and Luciana Scotti, and Aakash Chawade, and Ashutosh Mani
June 1999, The Journal of the Association of Physicians of India,
Shikha Kushwah, and Neha Shree Maurya, and Sandeep Kushwaha, and Luciana Scotti, and Aakash Chawade, and Ashutosh Mani
January 1945, Anales. Asociacion de Quimica y Farmacia del Uruguay,
Shikha Kushwah, and Neha Shree Maurya, and Sandeep Kushwaha, and Luciana Scotti, and Aakash Chawade, and Ashutosh Mani
May 1978, Indian journal of history of science,
Shikha Kushwah, and Neha Shree Maurya, and Sandeep Kushwaha, and Luciana Scotti, and Aakash Chawade, and Ashutosh Mani
January 2021, Indian heart journal,
Shikha Kushwah, and Neha Shree Maurya, and Sandeep Kushwaha, and Luciana Scotti, and Aakash Chawade, and Ashutosh Mani
January 2003, The Journal of the Association of Physicians of India,
Shikha Kushwah, and Neha Shree Maurya, and Sandeep Kushwaha, and Luciana Scotti, and Aakash Chawade, and Ashutosh Mani
January 2007, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
Shikha Kushwah, and Neha Shree Maurya, and Sandeep Kushwaha, and Luciana Scotti, and Aakash Chawade, and Ashutosh Mani
February 2012, American journal of hypertension,
Shikha Kushwah, and Neha Shree Maurya, and Sandeep Kushwaha, and Luciana Scotti, and Aakash Chawade, and Ashutosh Mani
May 2020, Iranian journal of public health,
Shikha Kushwah, and Neha Shree Maurya, and Sandeep Kushwaha, and Luciana Scotti, and Aakash Chawade, and Ashutosh Mani
January 1992, Sudhoffs Archiv,
Copied contents to your clipboard!