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A significantly lower vitamin C concentration has been found in the blood and particularly in the leukocytes of hypercholesterolemic diabetic patients than of healthy blood donors. Ascorbic acid administered in a dose of 500 mg per day for 12 months to metabolically stabilized hypercholesterolemic subjects with maturity-onset diabetes mellitus (diabetic diet without insulin or diabetic drugs) brought about a striking decline of cholesterolemia and a moderate decline of triglyceridemia. The serum lipid level in the control group given placebo remained unaltered. A daily administration of 500 mg of ascorbic acid for six months failed to affect the fasting level of serum immunoreactive insulin. It is assumed that the long-term administration of ascorbic acid to maturity-onset diabetics removed the tissue ascorbate deficiency and improved the liver ability to compensate the increased endogenous synthesis of cholesterol by its enhanced transformation to bile acids.
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B Zdichynec, and
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M Koziaková, and
O Cerná, and
L Ozdín, and
F Hrubá, and
V Nováková, and
E Sasko, and
M Gaher
June 1976,
JAMA,
E Ginter, and
B Zdichynec, and
O Holzerová, and
E Tichá, and
R Kobza, and
M Koziaková, and
O Cerná, and
L Ozdín, and
F Hrubá, and
V Nováková, and
E Sasko, and
M Gaher
August 1967,
Lancet (London, England),
E Ginter, and
B Zdichynec, and
O Holzerová, and
E Tichá, and
R Kobza, and
M Koziaková, and
O Cerná, and
L Ozdín, and
F Hrubá, and
V Nováková, and
E Sasko, and
M Gaher
January 1973,
Journal of the National Medical Association,
E Ginter, and
B Zdichynec, and
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R Kobza, and
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F Hrubá, and
V Nováková, and
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M Gaher
March 1981,
Journal of the Indian Medical Association,
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January 1979,
Current medical research and opinion,
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November 1965,
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E Ginter, and
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January 1967,
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September 1972,
British medical journal,
