BIOMAT Database Logo BIOMAT Database Logo

[Studies on positive inotropic agents. III. Synthesis of 6-(substituted 1-oxoalkyl)-2(1H)-quinolinone derivatives]. 1987

M Tominaga, and H Ogawa, and E Yo, and S Yamashita, and Y Yabuuchi, and K Nakagawa

UI MeSH Term Description Entries
D009200 Myocardial Contraction Contractile activity of the MYOCARDIUM. Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D011804 Quinolines
D002316 Cardiotonic Agents Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). Cardiac Stimulant,Cardiac Stimulants,Cardioprotective Agent,Cardioprotective Agents,Cardiotonic,Cardiotonic Agent,Cardiotonic Drug,Inotropic Agents, Positive Cardiac,Myocardial Stimulant,Myocardial Stimulants,Cardiotonic Drugs,Cardiotonics,Agent, Cardioprotective,Agent, Cardiotonic,Drug, Cardiotonic,Stimulant, Cardiac,Stimulant, Myocardial
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013268 Stimulation, Chemical The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical. Chemical Stimulation,Chemical Stimulations,Stimulations, Chemical
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D066298 In Vitro Techniques Methods to study reactions or processes taking place in an artificial environment outside the living organism. In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In

Related Publications

M Tominaga, and H Ogawa, and E Yo, and S Yamashita, and Y Yabuuchi, and K Nakagawa
Novel positive inotropic agents: synthesis and biological activities of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinone derivatives.
October 1992, Journal of medicinal chemistry,
M Tominaga, and H Ogawa, and E Yo, and S Yamashita, and Y Yabuuchi, and K Nakagawa
Studies on 2(1H)-quinolinone derivatives as neuroleptic agents I. Synthesis and biological activities of (4-phenyl-1-piperazinyl)-propoxy-2(1H)-quinolinone derivatives.
November 1988, Chemical & pharmaceutical bulletin,
M Tominaga, and H Ogawa, and E Yo, and S Yamashita, and Y Yabuuchi, and K Nakagawa
Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. Synthesis and antiulcer activities of optically active alpha-amino acid derivatives of 2(1H)-quinolinone and oxindole.
February 1987, Chemical & pharmaceutical bulletin,
M Tominaga, and H Ogawa, and E Yo, and S Yamashita, and Y Yabuuchi, and K Nakagawa
Compounds with positive inotropic activity, III: Synthesis of 4-aminoquinoline derivatives as potential positive inotropic agents.
September 1990, Archiv der Pharmazie,
M Tominaga, and H Ogawa, and E Yo, and S Yamashita, and Y Yabuuchi, and K Nakagawa
Design, synthesis and pharmacological evaluation of 6-hydroxy-4-methylquinolin-2(1H)-one derivatives as inotropic agents.
August 2009, Journal of enzyme inhibition and medicinal chemistry,
M Tominaga, and H Ogawa, and E Yo, and S Yamashita, and Y Yabuuchi, and K Nakagawa
Studies on hypolipidemic agents. III. Synthesis and esterase-inhibitory activity of omega-cycloalkyl-2-oxoalkyl arenesulfonates.
June 1987, Chemical & pharmaceutical bulletin,
M Tominaga, and H Ogawa, and E Yo, and S Yamashita, and Y Yabuuchi, and K Nakagawa
Studies on hypotensive agents. Synthesis of 1-substituted 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazoline diones.
July 1991, Chemical & pharmaceutical bulletin,
M Tominaga, and H Ogawa, and E Yo, and S Yamashita, and Y Yabuuchi, and K Nakagawa
The inhibitory effects of a positive inotropic quinolinone derivative, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212), on bone-marrow progenitor cells and peripheral lymphocytes.
January 1992, European journal of clinical pharmacology,
M Tominaga, and H Ogawa, and E Yo, and S Yamashita, and Y Yabuuchi, and K Nakagawa
Studies on cardiotonic agents. III. Synthesis of 1-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-3-substituted 2-imidazolidinone and 2-imidazolidinethione derivatives.
September 1990, Chemical & pharmaceutical bulletin,
M Tominaga, and H Ogawa, and E Yo, and S Yamashita, and Y Yabuuchi, and K Nakagawa
Studies on antifungal agents. 23. Novel substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)- 2-alkylisoxazolidine derivatives.
October 1988, Journal of medicinal chemistry,
Copied contents to your clipboard!