-transparent.png){kind=logo}
Protamine administration for heparin reversal after cardiopulmonary bypass on occasion is associated with mild to severe hemodynamic deterioration. The route of administration may modify these reactions. A prospective randomized study was done in 68 patients undergoing isolated coronary artery bypass grafting. The route of protamine administration was randomized in a balanced fashion between right atrium, left atrium, and aorta. The preoperative and operative characteristics of the three groups were similar. Hemodynamic measurements were recorded before cannulation, after removal of the venous drainage catheter, and 1 minute, 5 minutes, and 10 minutes after protamine administration. Hypotension occurred in 11 patients with no significant difference among the three groups. The hypotension was immediate in three patients in whom route of administration was the aorta. The overall hemodynamic changes observed for the three treatment groups were not significantly different. An analysis for type II error indicated that it was unlikely that an important difference had been missed. We conclude that the route of administration does not affect the hemodynamic changes associated with protamine administration. We did not observe a case of severe hemodynamic deterioration, so that we cannot assess the effect of route of administration on the severity of an anaphylactic reaction.
N M Katz, and
Y D Kim, and
R Siegelman, and
S A Ved, and
S W Ahmed, and
R B Wallace
June 1989,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
N M Katz, and
Y D Kim, and
R Siegelman, and
S A Ved, and
S W Ahmed, and
R B Wallace
January 1987,
The Journal of cardiovascular surgery,
N M Katz, and
Y D Kim, and
R Siegelman, and
S A Ved, and
S W Ahmed, and
R B Wallace
January 1982,
Kyobu geka. The Japanese journal of thoracic surgery,
N M Katz, and
Y D Kim, and
R Siegelman, and
S A Ved, and
S W Ahmed, and
R B Wallace
January 2010,
European heart journal,
N M Katz, and
Y D Kim, and
R Siegelman, and
S A Ved, and
S W Ahmed, and
R B Wallace
June 2005,
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova,
N M Katz, and
Y D Kim, and
R Siegelman, and
S A Ved, and
S W Ahmed, and
R B Wallace
October 1967,
The Annals of thoracic surgery,
N M Katz, and
Y D Kim, and
R Siegelman, and
S A Ved, and
S W Ahmed, and
R B Wallace
July 1985,
The Journal of thoracic and cardiovascular surgery,
N M Katz, and
Y D Kim, and
R Siegelman, and
S A Ved, and
S W Ahmed, and
R B Wallace
January 2008,
Asian cardiovascular & thoracic annals,
N M Katz, and
Y D Kim, and
R Siegelman, and
S A Ved, and
S W Ahmed, and
R B Wallace
January 1981,
Revista espanola de cardiologia,
N M Katz, and
Y D Kim, and
R Siegelman, and
S A Ved, and
S W Ahmed, and
R B Wallace
November 1991,
Anesthesiology,
