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The content and distribution of acetylcholinesterase (AChE) activity in the skeletal muscle disorder malignant hyperthermia (MH) was examined. The AChE activity of sarcolemma membranes isolated from MH-susceptible (MHS) swine was increased twofold when compared with normal sarcolemma. The total AChE activity of muscle extracts was also doubled in MHS tissue; however, the relative distribution between low-salt extractable (globular forms) and high-salt extractable (asymmetric forms) AChE activities were similar in MHS and normal muscle. Our results suggest that, for as yet unexplained reasons, both the sarcolemmal and total AChE activity of skeletal muscle is increased in porcine MH.
J R Mickelson, and
H S Thatte, and
T M Beaudry, and
E M Gallant, and
C F Louis
July 1986,
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
J R Mickelson, and
H S Thatte, and
T M Beaudry, and
E M Gallant, and
C F Louis
January 1977,
Canadian Anaesthetists' Society journal,
J R Mickelson, and
H S Thatte, and
T M Beaudry, and
E M Gallant, and
C F Louis
September 1979,
European journal of pharmacology,
J R Mickelson, and
H S Thatte, and
T M Beaudry, and
E M Gallant, and
C F Louis
November 1996,
Anesthesia and analgesia,
J R Mickelson, and
H S Thatte, and
T M Beaudry, and
E M Gallant, and
C F Louis
October 1995,
British journal of anaesthesia,
J R Mickelson, and
H S Thatte, and
T M Beaudry, and
E M Gallant, and
C F Louis
January 1979,
Anesthesia and analgesia,
J R Mickelson, and
H S Thatte, and
T M Beaudry, and
E M Gallant, and
C F Louis
July 1986,
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
J R Mickelson, and
H S Thatte, and
T M Beaudry, and
E M Gallant, and
C F Louis
March 2004,
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS,
J R Mickelson, and
H S Thatte, and
T M Beaudry, and
E M Gallant, and
C F Louis
February 2000,
Muscle & nerve,
J R Mickelson, and
H S Thatte, and
T M Beaudry, and
E M Gallant, and
C F Louis
November 1981,
The Journal of clinical investigation,
