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Malignant Melanocytic Matricoma: A Rare Skin Tumor That Can Clinically Mimic Melanoma. 2023

Layla Tahiri Elousrouti, and Imane Fadlallah, and Meryem Soughi, and Houda Elabbad, and Hanane Baybay, and Fatima Zahra Mernissi, and Hinde Elfatemi, and Laila Chbani, and Nawal Hammas
Department of Pathology, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Biomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy, Fez, MAR.

Malignant melanocytic matricoma (MMM) is an extremely rare skin malignant neoplasm composed of epithelial cells with matrical differentiation and dendritic melanocytes. We found only 11 cases reported in the literature to date according to the databases consulted (PubMed/Medline, Scopus, and Web of Science). Here, we report a case of MMM in an 86-year-old woman. A histological examination showed a dermal tumor with a deep infiltrative pattern, without an epidermal connection. On immunohistochemical staining, tumor cells were positive for cytokeratin AE1/AE3, p63, and beta-catenin (nuclear and cytoplasmic staining) and negative for HMB45, Melan-A, S-100 protein, and androgen receptor. Melanic antibodies highlighted scattered dendritic melanocytes in tumor sheets. The findings did not support the diagnosis of melanoma, poorly differentiated sebaceous carcinoma, and basal cell carcinoma, but supported the diagnosis of MMM.

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