Biomaterial Database

Influence of mixed-ligand complexes on retention and distribution of radioniobium in mice. 1987

A Gachályi, and J Naményi, and I Szegedi, and L P Varga

Frédéric Joliot-Curie, National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary.

The individual effects of desferrioxamine B (DFOA), Na3Ca diethylenetriaminepentaacetic acid (DTPA), Na-salicylate, DL-penicillamine, and 2-aminoethylisothiouronium bromide hydrobromide, as well as the effect of mixed-ligand treatment on the retention and elimination of 95Nb in mice have been examined. It was found that 95Nb could easily be mobilized by a single dose of DFOA, but the best result was obtained with the DFOA and DTPA combination. Mixed-ligand treatment did not change the deposition characteristics and translocation kinetics of 95Nb.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009556	Niobium	A metal element atomic number 41, atomic weight 92.906, symbol Nb.	Niobium-93,Niobium 93
D010396	Penicillamine	3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.	Dimethylcysteine,Mercaptovaline,beta,beta-Dimethylcysteine,Copper Penicillaminate,Cuprenil,Cuprimine,D-3-Mercaptovaline,D-Penicillamine,Metalcaptase,D 3 Mercaptovaline,D Penicillamine,Penicillaminate, Copper,beta,beta Dimethylcysteine
D011868	Radioisotopes	Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Daughter Isotope,Daughter Nuclide,Radioactive Isotope,Radioactive Isotopes,Radiogenic Isotope,Radioisotope,Radionuclide,Radionuclides,Daughter Nuclides,Daugter Isotopes,Radiogenic Isotopes,Isotope, Daughter,Isotope, Radioactive,Isotope, Radiogenic,Isotopes, Daugter,Isotopes, Radioactive,Isotopes, Radiogenic,Nuclide, Daughter,Nuclides, Daughter
D002614	Chelating Agents	Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.	Chelating Agent,Chelator,Complexons,Metal Antagonists,Chelators,Metal Chelating Agents,Agent, Chelating,Agents, Chelating,Agents, Metal Chelating,Antagonists, Metal,Chelating Agents, Metal
D003666	Decontamination	The removal of contaminating material, such as radioactive materials, biological materials, or CHEMICAL WARFARE AGENTS, from a person or object.
D003676	Deferoxamine	Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.	Desferrioxamine,Deferoxamine B,Deferoxamine Mesilate,Deferoxamine Mesylate,Deferoxamine Methanesulfonate,Deferoximine,Deferrioxamine B,Desferal,Desferioximine,Desferrioxamine B,Desferrioxamine B Mesylate,Desferroxamine,Mesilate, Deferoxamine,Mesylate, Deferoxamine,Mesylate, Desferrioxamine B,Methanesulfonate, Deferoxamine
D004359	Drug Therapy, Combination	Therapy with two or more separate preparations given for a combined effect.	Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D004369	Pentetic Acid	An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	DTPA,Diethylenetriamine Pentaacetic Acid,Pentetates,Penthanil,Ca-DTPA,CaDTPA,CaNa-DTPA,Calcium Trisodium Pentetate,DETAPAC,Indium-DTPA,Mn-Dtpa,Pentacin,Pentacine,Pentaind,Pentetate Calcium Trisodium,Pentetate Zinc Trisodium,Sn-DTPA,Zinc-DTPA,Indium DTPA,Pentaacetic Acid, Diethylenetriamine,Pentetate, Calcium Trisodium,Zinc DTPA
D000338	beta-Aminoethyl Isothiourea	A radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis.	2-Aminoethylisothiuronium Bromide,beta-Aminoethylisothiuronium Diacetate,beta-Aminoethylisothiuronium Dihydrobromide,2-Aminoethylisothiuronium Diacetate,2-Aminoethylisothiuronium Dihydrochloride,2-Aminoethylisothiuronium Dihydroiodide,2-Aminoethylisothiuronium Diperchlorate,2-Aminoethylisothiuronium Monohydrobromide,2-Aminoethylisothiuronium Phosphate (1:1),2-Aminoethylisothiuronium Sulfate (1:1),AET,Aminoethylisothiuronium Bromide Hydrobromide,Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide,Isothiourea, (2-Aminoethyl),Ixecur,S-(2-Aminoethyl)isothiourea,beta-Aminoethylisothiuronium Bromide,beta-Aminoethylisothiuronium Dihydrochloride,beta-Aminoethylisothiuronium Dihydroiodide,beta-Aminoethylisothiuronium Diperchlorate,beta-Aminoethylisothiuronium Monohydrobromide,beta-Aminoethylisothiuronium Phosphate (1:1),beta-Aminoethylisothiuronium Sulfate (1:1),2 Aminoethylisothiuronium Bromide,2 Aminoethylisothiuronium Diacetate,2 Aminoethylisothiuronium Dihydrochloride,2 Aminoethylisothiuronium Dihydroiodide,2 Aminoethylisothiuronium Diperchlorate,2 Aminoethylisothiuronium Monohydrobromide,Bromide, 2-Aminoethylisothiuronium,Bromide, beta-Aminoethylisothiuronium,Diacetate, 2-Aminoethylisothiuronium,Diacetate, beta-Aminoethylisothiuronium,Dihydrobromide, beta-Aminoethylisothiuronium,Dihydrochloride, 2-Aminoethylisothiuronium,Dihydrochloride, beta-Aminoethylisothiuronium,Dihydroiodide, 2-Aminoethylisothiuronium,Dihydroiodide, beta-Aminoethylisothiuronium,Diperchlorate, 2-Aminoethylisothiuronium,Diperchlorate, beta-Aminoethylisothiuronium,Hydrobromide, Aminoethylisothiuronium Bromide,Isothiourea, beta-Aminoethyl,Monohydrobromide, 2-Aminoethylisothiuronium,Monohydrobromide, beta-Aminoethylisothiuronium,beta Aminoethyl Isothiourea,beta Aminoethylisothiuronium Bromide,beta Aminoethylisothiuronium Diacetate,beta Aminoethylisothiuronium Dihydrobromide,beta Aminoethylisothiuronium Dihydrochloride,beta Aminoethylisothiuronium Dihydroiodide,beta Aminoethylisothiuronium Diperchlorate,beta Aminoethylisothiuronium Monohydrobromide