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A comparative study of pipemidic acid and nitrofurantoin in the treatment of uncomplicated urinary tract infections. 1987

E C Meyer, and H S Schoeman
Department of Pharmacology, University of Pretoria.

In an open uncontrolled trial 60 women with confirmed uncomplicated urinary tract infections were randomly allocated to receive either pipemidic acid (Septidron; Ethimed) or nitrofurantoin for 10 days. Urine cultures were done on day 1 and day 10. No statistical difference was found in the subjective and objective assessments of the response to the two medications and it is concluded that pipemidic acid is a satisfactory and effective alternative to nitrofurantoin in the treatment of uncomplicated urinary tract infections in women.

UI MeSH Term Description Entries
D009539 Nicotinic Acids 2-, 3-, or 4-Pyridinecarboxylic acids. Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. The 3-carboxy derivative (NIACIN) is active as a vitamin. Acids, Nicotinic
D009582 Nitrofurantoin A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression. Furadantin,Furadantine,Furadoine,Furadonine,Furantoin,Macrodantin,Nitrofurantoin Sodium Salt,Nitrofurantoin, Monohydrate
D010876 Pipemidic Acid Antimicrobial against Gram negative and some Gram positive bacteria. It is protein bound and concentrated in bile and urine and used for gastrointestinal, biliary, and urinary infections. Piperamic Acid,Deblaston,Galusan,Nuril,Palin,Pipram,Urisan,Uropipemid,Acid, Pipemidic,Acid, Piperamic
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014552 Urinary Tract Infections Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA. Infection, Urinary Tract,Infections, Urinary Tract,Tract Infection, Urinary,Tract Infections, Urinary,Urinary Tract Infection

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