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Introduction: Our aim was to investigate biomarkers of neonatal pain and their association with two pain scales. Methods: This prospective study included 54 full-term neonates. Levels of substance P (SubP), neurokinin A (NKA), neuropeptide Y (NPY), and cortisol were recorded and two pain scales (Premature Infant Pain Profile [PIPP] and Neonatal Infant Pain Scale [NIPS]) were used. Results: A statistically significant decrease in the levels of NPY (p = 0.02) and NKA (p = 0.03) was detected. A significant increase in NIPS scale (p < 0.001) and PIPP scale (p < 0.001) postpainful intervention was also detected. There was a positive correlation between cortisol and SubP (p = 0.01), NKA and NPY (p < 0.001) and between NIPS and PIPP (p < 0.001). A negative correlation was found for NPY with SubP (p = 0.004), cortisol (p = 0.02), NIPS (p = 0.001) and PIPP (p = 0.002). Conclusions: Novel biomarkers and pain scales may help in designing an objective tool for the quantification of neonatal pain in the everyday practice.
Christina Dionysakopoulou, and
Loukia Lianou, and
Barbara Boutopoulou, and
Margarita Giannakopoulou, and
Efrosini Vlachioti, and
Despoina Koumpagioti, and
Evangelos Bozas, and
Vasiliki Matziou
October 2019,
Scientific reports,
Christina Dionysakopoulou, and
Loukia Lianou, and
Barbara Boutopoulou, and
Margarita Giannakopoulou, and
Efrosini Vlachioti, and
Despoina Koumpagioti, and
Evangelos Bozas, and
Vasiliki Matziou
January 1987,
Scandinavian journal of gastroenterology,
Christina Dionysakopoulou, and
Loukia Lianou, and
Barbara Boutopoulou, and
Margarita Giannakopoulou, and
Efrosini Vlachioti, and
Despoina Koumpagioti, and
Evangelos Bozas, and
Vasiliki Matziou
June 2023,
The international journal of lower extremity wounds,
Christina Dionysakopoulou, and
Loukia Lianou, and
Barbara Boutopoulou, and
Margarita Giannakopoulou, and
Efrosini Vlachioti, and
Despoina Koumpagioti, and
Evangelos Bozas, and
Vasiliki Matziou
November 1992,
Brain research,
Christina Dionysakopoulou, and
Loukia Lianou, and
Barbara Boutopoulou, and
Margarita Giannakopoulou, and
Efrosini Vlachioti, and
Despoina Koumpagioti, and
Evangelos Bozas, and
Vasiliki Matziou
June 1983,
Lancet (London, England),
Christina Dionysakopoulou, and
Loukia Lianou, and
Barbara Boutopoulou, and
Margarita Giannakopoulou, and
Efrosini Vlachioti, and
Despoina Koumpagioti, and
Evangelos Bozas, and
Vasiliki Matziou
July 1991,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
Christina Dionysakopoulou, and
Loukia Lianou, and
Barbara Boutopoulou, and
Margarita Giannakopoulou, and
Efrosini Vlachioti, and
Despoina Koumpagioti, and
Evangelos Bozas, and
Vasiliki Matziou
December 1986,
Brain research,
Christina Dionysakopoulou, and
Loukia Lianou, and
Barbara Boutopoulou, and
Margarita Giannakopoulou, and
Efrosini Vlachioti, and
Despoina Koumpagioti, and
Evangelos Bozas, and
Vasiliki Matziou
January 1992,
Postepy biochemii,
Christina Dionysakopoulou, and
Loukia Lianou, and
Barbara Boutopoulou, and
Margarita Giannakopoulou, and
Efrosini Vlachioti, and
Despoina Koumpagioti, and
Evangelos Bozas, and
Vasiliki Matziou
January 2023,
BioFactors (Oxford, England),
Christina Dionysakopoulou, and
Loukia Lianou, and
Barbara Boutopoulou, and
Margarita Giannakopoulou, and
Efrosini Vlachioti, and
Despoina Koumpagioti, and
Evangelos Bozas, and
Vasiliki Matziou
February 1995,
Archives of oral biology,
