Changes in brain monoamine content and metabolism induced by paraoxon and soman intoxication. Effect of atropine. 1987

C Coudray-Lucas, and A Le Guen, and M Prioux-Guyonneau, and Y Cohen, and J Wepierre
Laboratoire de Pharmacologie, U.A.-C.N.R.S. 594, Faculté de Pharmacie, F Châtenay-Malabry, France.

1. Soman induced a decrease in hypothalamic, hippocampal and cortical noradrenaline, an increase in hippocampal and cortical dopamine and an increase in hypothalamic serotonin while paraoxon did not modify these neurotransmitter concentrations. The increases in 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindole acetic acid produced by the two drugs witness an accelerated turnover of dopamine and serotonin. 2. Atropine pretreatment completely antagonized the paraoxon-induced changes but only partially suppressed the soman-induced modifications. 3. These data suggest that soman produces a direct effect on monoamine metabolism which is not related to acetylcholine accumulation.

UI MeSH Term Description Entries
D008297 Male Males
D010261 Paraoxon An organophosphate cholinesterase inhibitor that is used as a pesticide. Diethyl-p-Nitrophenyl Phosphate,E-600,Fosfakol,Phosphacol,Diethyl p Nitrophenyl Phosphate,E 600,E600,Phosphate, Diethyl-p-Nitrophenyl
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001285 Atropine An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine. AtroPen,Atropin Augenöl,Atropine Sulfate,Atropine Sulfate Anhydrous,Atropinol,Anhydrous, Atropine Sulfate,Augenöl, Atropin,Sulfate Anhydrous, Atropine,Sulfate, Atropine
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D001679 Biogenic Amines A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology. Amines, Biogenic,Biogenic Amine,Amine, Biogenic
D012999 Soman An organophosphorus compound that inhibits cholinesterase. It causes seizures and has been used as a chemical warfare agent. Pinacolyl Methylphosphonofluoridate,Methylphosphonofluoridate, Pinacolyl

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