BIOMAT Database Logo BIOMAT Database Logo

Obesity, elevated levels of fasting plasma glucose and type 2 diabetes are associated with aortic stiffness. 2023

Viera Kupcova, and Jan Murin, and Sona Wimmerova, and Maria Potocarova, and Ladislav Turecky, and Jozef Bulas

OBJECTIVE Obesity and metabolic syndrome (MetS) are associated with structural and functional vascular abnormalities. MetS and its components may increase arterial stiffness and the risk of cardiovascular events. However, the relationship of MetS and its components, including obesity, with arterial stiffness is still not fully understood. METHODS In a group of 116 patients undergoing treatment for hypertension, we searched for the relationships between parameters of MetS and aortic stiffness expressed by pulse wave velocity (PWVAo). PWVAo was measured using an arteriograph working on the oscillometric principle, and pulse wave analysis (PWA) for noninvasive assessment of the parameters of central hemodynamics. RESULTS From the cluster of parameters of MetS we found a significant association between body mass index (BMI) and aortic stiffness, and between fasting plasma glucose/type 2 diabetes (FPG/T2DM) and aortic stiffness. We did not find significant relationships between other components of MetS (HDL cholesterol and triglycerides) and aortic stiffness, based on the influence of hypolipidemic therapy. Arterial stiffness increased with age and was higher in females. CONCLUSIONS Arterial stiffness was associated with age, sex, and MetS components (BMI and FPG/T2DM). Surprisingly, the parameters of dyslipidemia do not influence stiffness parameters, which can be explained by hypolipidemic therapy. The influence of hypolipidemic therapy should therefore be borne in mind when evaluating arterial tree function (Tab. 15, Ref. 62). Text in PDF www.elis.sk Keywords: obesity, fasting plasma glucose, type 2 diabetes, aortic stiffness, metabolic syndrome, arterial hypertension, cardiovascular risk.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D005215 Fasting Abstaining from FOOD. Hunger Strike,Hunger Strikes,Strike, Hunger,Strikes, Hunger
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D059289 Vascular Stiffness Loss of vascular ELASTICITY due to factors such as AGING; and ARTERIOSCLEROSIS. Increased arterial stiffness is one of the RISK FACTORS for many CARDIOVASCULAR DISEASES. Arterial Stiffness,Aortic Stiffness,Aortic Stiffnesses,Arterial Stiffnesses,Stiffness, Aortic,Stiffness, Arterial,Stiffness, Vascular,Vascular Stiffnesses
D024821 Metabolic Syndrome A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. Cardiometabolic Syndrome,Insulin Resistance Syndrome X,Metabolic Syndrome X,Reaven Syndrome X,Dysmetabolic Syndrome X,Metabolic Cardiovascular Syndrome,Metabolic X Syndrome,Syndrome X, Insulin Resistance,Syndrome X, Metabolic,Cardiometabolic Syndromes,Cardiovascular Syndrome, Metabolic,Cardiovascular Syndromes, Metabolic,Metabolic Syndromes,Syndrome X, Dysmetabolic,Syndrome X, Reaven,Syndrome, Cardiometabolic,Syndrome, Metabolic,Syndrome, Metabolic Cardiovascular,Syndrome, Metabolic X,Syndromes, Cardiometabolic,Syndromes, Metabolic,X Syndrome, Metabolic

Related Publications

Viera Kupcova, and Jan Murin, and Sona Wimmerova, and Maria Potocarova, and Ladislav Turecky, and Jozef Bulas
Elevated alanine aminotransferase levels are associated with impaired fasting glucose and type 2 diabetes in obese women.
January 2012, Annals of hepatology,
Viera Kupcova, and Jan Murin, and Sona Wimmerova, and Maria Potocarova, and Ladislav Turecky, and Jozef Bulas
Normal fasting plasma glucose levels and type 2 diabetes.
January 2006, The New England journal of medicine,
Viera Kupcova, and Jan Murin, and Sona Wimmerova, and Maria Potocarova, and Ladislav Turecky, and Jozef Bulas
Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women.
December 2017, Pediatric diabetes,
Viera Kupcova, and Jan Murin, and Sona Wimmerova, and Maria Potocarova, and Ladislav Turecky, and Jozef Bulas
Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women.
February 2020, Pediatric diabetes,
Viera Kupcova, and Jan Murin, and Sona Wimmerova, and Maria Potocarova, and Ladislav Turecky, and Jozef Bulas
Are lower fasting plasma glucose levels at diagnosis of type 2 diabetes associated with improved outcomes?: U.K. prospective diabetes study 61.
August 2002, Diabetes care,
Viera Kupcova, and Jan Murin, and Sona Wimmerova, and Maria Potocarova, and Ladislav Turecky, and Jozef Bulas
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes.
January 2018, EBioMedicine,
Viera Kupcova, and Jan Murin, and Sona Wimmerova, and Maria Potocarova, and Ladislav Turecky, and Jozef Bulas
Elevated total plasma homocysteine levels are associated with type 2 diabetes in women with hypertension.
January 2015, Asia Pacific journal of clinical nutrition,
Viera Kupcova, and Jan Murin, and Sona Wimmerova, and Maria Potocarova, and Ladislav Turecky, and Jozef Bulas
Normal fasting plasma glucose levels and type 2 diabetes in young men.
October 2005, The New England journal of medicine,
Viera Kupcova, and Jan Murin, and Sona Wimmerova, and Maria Potocarova, and Ladislav Turecky, and Jozef Bulas
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.
January 2009, Nature genetics,
Viera Kupcova, and Jan Murin, and Sona Wimmerova, and Maria Potocarova, and Ladislav Turecky, and Jozef Bulas
Fasting plasma glucose variability and HbA1c are associated with peripheral artery disease risk in type 2 diabetes.
January 2020, Cardiovascular diabetology,
Copied contents to your clipboard!