Biomaterial Database

[Studies on dichlorvos (DDVP). I. Testing of dichlorvos for carcinogenic activity in mice]. 1987

K H Horn, and B Teichmann, and T Schramm

Zentralinstitut für Krebsforschung, Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.

Up to now the question remained open, whether or not the pesticide Dichlorvos, should be classified as a carcinogen. We report on our results of long-time oral administration to male and female C57B1/6/Bln-mice of Dichlorvos to test the compound for carcinogenic activity. Dichlorvos significantly increased the incidence of focal hyperplasias (transitional cell hyperplasias) of the urinary bladder in male and female mice and decreased significantly the incidence of mixed lymphomas in mice of both sexes as compared with control animals (treated with solvent or untreated). There were no neoplastic lesions found including papillomas of the urinary bladder which could be attributed to the treatment of the animals with Dichlorvos.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009374	Neoplasms, Experimental	Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.	Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D011230	Precancerous Conditions	Pathological conditions that tend eventually to become malignant.	Preneoplastic Conditions,Condition, Preneoplastic,Conditions, Preneoplastic,Preneoplastic Condition,Condition, Precancerous,Conditions, Precancerous,Precancerous Condition
D004006	Dichlorvos	An organophosphorus insecticide that inhibits ACETYLCHOLINESTERASE.	DDVP,Dichlofos,Dichlorophos,Dimethyl Dichlorovinyl Phosphate,Divipan,Novotox,Phosphoric acid 2,2-dichloroethenyl dimethyl ester,Phosphoric acid 2,2 dichloroethenyl dimethyl ester
D005260	Female		Females
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus