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Previous studies in prokaryotes and in eukaryotic cell lines have indicated the possible existence of more than one dTTP pool accessible to DNA synthesis. To investigate this possibility in eukaryotes in vivo, the incorporation of [3H] deoxythymidine into nuclear matrix-attached DNA and intracellular dTTP was examined in regenerating rat liver. The labeling of matrix DNA reached a maximum after a 5 min pulse and then began to rapidly decrease. Conversely, [3H] deoxythymidine incorporation into dTTP began to increase after 5 min and peaked 10 min after injection. Since the peak specific activity for [3H] deoxythymidine incorporation into matrix DNA precedes that into dTTP, there seems to be channeling of exogenous thymidine directly to sites of DNA replication, bypassing existing nucleotide pools.
P L Panzeter, and
J L Etheredge, and
D E Kizer, and
D P Ringer
October 1972,
Developmental biology,
P L Panzeter, and
J L Etheredge, and
D E Kizer, and
D P Ringer
July 1972,
Experimental cell research,
P L Panzeter, and
J L Etheredge, and
D E Kizer, and
D P Ringer
March 1986,
American journal of hematology,
P L Panzeter, and
J L Etheredge, and
D E Kizer, and
D P Ringer
October 1982,
Revista espanola de las enfermedades del aparato digestivo,
P L Panzeter, and
J L Etheredge, and
D E Kizer, and
D P Ringer
November 1960,
Biochemical and biophysical research communications,
P L Panzeter, and
J L Etheredge, and
D E Kizer, and
D P Ringer
August 1967,
Biochimica et biophysica acta,
P L Panzeter, and
J L Etheredge, and
D E Kizer, and
D P Ringer
October 1961,
The Journal of biophysical and biochemical cytology,
P L Panzeter, and
J L Etheredge, and
D E Kizer, and
D P Ringer
December 1972,
Biochimica et biophysica acta,
P L Panzeter, and
J L Etheredge, and
D E Kizer, and
D P Ringer
October 1968,
The Biochemical journal,
P L Panzeter, and
J L Etheredge, and
D E Kizer, and
D P Ringer
November 1982,
The Journal of biological chemistry,
