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Calcium glucarate (CGT), an inhibitor of beta-glucuronidase, is a potent inhibitor of chemically-induced tumors when administered orally. The present study was undertaken to determine the effects of CGT on the promotion of hepatocarcinogenesis by phenobarbital following initiation with diethylnitrosamine (DENA). Partially hepatectomized, DENA-initiated female Sprague-Dawley rats, previously maintained only on chow diet for 2 months, were supplemented with either 0.05% phenobarbital alone or 0.05% phenobarbital plus 4% dietary CGT, for varying time intervals up to 6 months. Histopathologic evaluation of the liver sections showed that CGT significantly delayed the development of altered hepatic foci (AHF). By the seventh month post-initiation, however, the frequency and severity of changes seen in the livers of experimental animals approximated those of the controls.
O A Oredipe, and
R F Barth, and
M Hanausek-Walaszek, and
I Sautins, and
Z Walaszek, and
T E Webb
August 1989,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
O A Oredipe, and
R F Barth, and
M Hanausek-Walaszek, and
I Sautins, and
Z Walaszek, and
T E Webb
September 1993,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
O A Oredipe, and
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M Hanausek-Walaszek, and
I Sautins, and
Z Walaszek, and
T E Webb
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T E Webb
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Carcinogenesis,
O A Oredipe, and
R F Barth, and
M Hanausek-Walaszek, and
I Sautins, and
Z Walaszek, and
T E Webb
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Carcinogenesis,
O A Oredipe, and
R F Barth, and
M Hanausek-Walaszek, and
I Sautins, and
Z Walaszek, and
T E Webb
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Molecular carcinogenesis,
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R F Barth, and
M Hanausek-Walaszek, and
I Sautins, and
Z Walaszek, and
T E Webb
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Cancer letters,
O A Oredipe, and
R F Barth, and
M Hanausek-Walaszek, and
I Sautins, and
Z Walaszek, and
T E Webb
May 1987,
Cancer research,
O A Oredipe, and
R F Barth, and
M Hanausek-Walaszek, and
I Sautins, and
Z Walaszek, and
T E Webb
April 1987,
Carcinogenesis,
O A Oredipe, and
R F Barth, and
M Hanausek-Walaszek, and
I Sautins, and
Z Walaszek, and
T E Webb
February 2003,
Cancer science,
