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Thirty patients with progressive metastatic breast cancer and one prior chemotherapy regimen were treated with iproplatin at a starting dose of 300 mg/m2 iv every 3 weeks. After the first 11 patients, the starting dose was decreased to 270 mg/m2. There were one complete remission, three partial remissions, and two minor responses. Responses were observed in soft tissue and osseous and visceral areas. Grade 3 nausea and vomiting were observed in 38% of patients, and grade 3 diarrhea occurred in 31%. The dose-limiting toxicity was thrombocytopenia, which required dose de-escalation in 15 patients. No nephrotoxicity, neurotoxicity, or ototoxicity was observed. Iproplatin has modest antitumor activity in this group of previously treated patients with metastatic breast cancer.
G N Hortobagyi, and
D Frye, and
F A Holmes, and
V Hug, and
G Fraschini, and
A U Buzdar
January 1988,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
G N Hortobagyi, and
D Frye, and
F A Holmes, and
V Hug, and
G Fraschini, and
A U Buzdar
January 1982,
Cancer chemotherapy and pharmacology,
G N Hortobagyi, and
D Frye, and
F A Holmes, and
V Hug, and
G Fraschini, and
A U Buzdar
August 1982,
American journal of clinical oncology,
G N Hortobagyi, and
D Frye, and
F A Holmes, and
V Hug, and
G Fraschini, and
A U Buzdar
December 1977,
Cancer treatment reports,
G N Hortobagyi, and
D Frye, and
F A Holmes, and
V Hug, and
G Fraschini, and
A U Buzdar
October 2001,
Cancer,
G N Hortobagyi, and
D Frye, and
F A Holmes, and
V Hug, and
G Fraschini, and
A U Buzdar
January 1999,
European journal of cancer (Oxford, England : 1990),
G N Hortobagyi, and
D Frye, and
F A Holmes, and
V Hug, and
G Fraschini, and
A U Buzdar
April 1989,
American journal of clinical oncology,
G N Hortobagyi, and
D Frye, and
F A Holmes, and
V Hug, and
G Fraschini, and
A U Buzdar
January 1990,
European journal of cancer (Oxford, England : 1990),
G N Hortobagyi, and
D Frye, and
F A Holmes, and
V Hug, and
G Fraschini, and
A U Buzdar
June 1990,
Onkologie,
G N Hortobagyi, and
D Frye, and
F A Holmes, and
V Hug, and
G Fraschini, and
A U Buzdar
February 1989,
British journal of cancer,
