Sex differences in brain metabolic connectivity architecture in probable dementia with Lewy bodies. 2023

Silvia Paola Caminiti, and Cecilia Boccalini, and Nicolas Nicastro, and Valentina Garibotto, and Daniela Perani, and
School of Psychology, Vita-Salute San Raffaele University, Milan, Italy; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

We investigated how sex modulates metabolic connectivity alterations in probable dementia with Lewy bodies (pDLB). We included 131 pDLB patients (males/females: 58/73) and similarly aged healthy controls (HC) (male/female: 59/75) with available (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans. We assessed (1) sex differences in the whole-brain connectivity, identifying pathological hubs, (2) connectivity alterations in functional pathways of the neurotransmitter systems, (3) Resting State Networks (RSNs) integrity. Both pDLBM (males) and pDLBF (females) shared dysfunctional hubs in the insula, Rolandic operculum, and inferior parietal lobule, but the pDLBM group showed more severe and diffuse whole-brain connectivity alterations. Neurotransmitters connectivity analysis revealed common alterations in dopaminergic and noradrenergic pathways. Sex differences emerged particularly in the Ch4-perisylvian division, with pDLBM showing more severe alterations than pDLBF. The RSNs analysis showed no sex differences, with decreased connectivity strength in the primary visual, posterior default mode, and attention networks in both groups. Extensive connectivity changes characterize both males and females in the dementia stage, with a major vulnerability of cholinergic neurotransmitter systems in males, possibly contributing to the observed different clinical phenotypes.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D001931 Brain Mapping Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures. Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000087623 Insular Cortex A pyramidal shaped region of cerebral cortex located deep below the lateral fissure in PRIMATES. It is surrounded by the SUPERIOR TEMPORAL GYRUS, the rostral PARIETAL LOBE, the INFERIOR FRONTAL GYRUS and the ORBITAL GYRI. It is the primary gustatory cortex and is involved in sensorimotor and somatosensory as well as socioemotional functions. Brodmann Area 13,Brodmann Area 14,Brodmann Area 15,Brodmann Area 16,Brodmann Area 43,Brodmann's Area 13,Brodmann's Area 14,Brodmann's Area 15,Brodmann's Area 16,Brodmann's Area 43,Central Lobe,Gustatory Cortex,Insula of Reil,Insular Gyrus,Insular Region,Lobus Insularis,Opercular Cortex,Primary Gustatory Cortex,Visceral Cortex,Area 13, Brodmann,Area 13, Brodmann's,Area 14, Brodmann,Area 14, Brodmann's,Area 15, Brodmann,Area 15, Brodmann's,Area 16, Brodmann,Area 16, Brodmann's,Area 43, Brodmann,Area 43, Brodmann's,Brodmanns Area 13,Brodmanns Area 14,Brodmanns Area 15,Brodmanns Area 16,Brodmanns Area 43,Central Lobes,Cortex, Gustatory,Cortex, Insular,Cortex, Opercular,Cortex, Primary Gustatory,Cortex, Visceral,Gustatory Cortex, Primary,Gyrus, Insular,Insular Cortices,Insular Regions,Lobe, Central,Primary Gustatory Cortices,Region, Insular,Visceral Cortices
D049268 Positron-Emission Tomography An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower. PET Imaging,PET Scan,Positron-Emission Tomography Imaging,Tomography, Positron-Emission,Imaging, PET,Imaging, Positron-Emission Tomography,PET Imagings,PET Scans,Positron Emission Tomography,Positron Emission Tomography Imaging,Positron-Emission Tomography Imagings,Scan, PET,Tomography Imaging, Positron-Emission,Tomography, Positron Emission
D020961 Lewy Body Disease A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124) Dementia, Lewy Body,Diffuse Lewy Body Disease,Cortical Lewy Body Disease,Lewy Body Dementia,Lewy Body Disease, Cortical,Lewy Body Disease, Diffuse,Lewy Body Type Senile Dementia

Related Publications

Silvia Paola Caminiti, and Cecilia Boccalini, and Nicolas Nicastro, and Valentina Garibotto, and Daniela Perani, and
January 2023, Research square,
Silvia Paola Caminiti, and Cecilia Boccalini, and Nicolas Nicastro, and Valentina Garibotto, and Daniela Perani, and
December 2023, Alzheimer's & dementia : the journal of the Alzheimer's Association,
Silvia Paola Caminiti, and Cecilia Boccalini, and Nicolas Nicastro, and Valentina Garibotto, and Daniela Perani, and
January 2022, Frontiers in neurology,
Silvia Paola Caminiti, and Cecilia Boccalini, and Nicolas Nicastro, and Valentina Garibotto, and Daniela Perani, and
January 2023, Research square,
Silvia Paola Caminiti, and Cecilia Boccalini, and Nicolas Nicastro, and Valentina Garibotto, and Daniela Perani, and
July 2021, Journal of neurology, neurosurgery, and psychiatry,
Silvia Paola Caminiti, and Cecilia Boccalini, and Nicolas Nicastro, and Valentina Garibotto, and Daniela Perani, and
April 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
Silvia Paola Caminiti, and Cecilia Boccalini, and Nicolas Nicastro, and Valentina Garibotto, and Daniela Perani, and
April 2021, Journal of Alzheimer's disease reports,
Silvia Paola Caminiti, and Cecilia Boccalini, and Nicolas Nicastro, and Valentina Garibotto, and Daniela Perani, and
December 2002, Canadian journal of psychiatry. Revue canadienne de psychiatrie,
Silvia Paola Caminiti, and Cecilia Boccalini, and Nicolas Nicastro, and Valentina Garibotto, and Daniela Perani, and
September 2017, BMJ case reports,
Silvia Paola Caminiti, and Cecilia Boccalini, and Nicolas Nicastro, and Valentina Garibotto, and Daniela Perani, and
July 2021, Harefuah,
Copied contents to your clipboard!