Biomaterial Database

Hemodynamic evaluation of ibuprofen in canine hypovolemic shock. 1987

K C Beamer, and T Daly, and T Vargish

Department of Surgery, West Virginia University School of Medicine, Morgantown 26506.

This study was done to evaluate the role of ibuprofen, a cyclooxygenase inhibitor, in a standard model of hypovolemic shock. Fifteen dogs were subjected to fixed mean arterial blood pressure (MABP) shock (40-45 mmHg) for 45 min and then treated with physiologic saline (NS), low-dose ibuprofen (6.25 mg/kg), and high-dose ibuprofen (12.5 mg/kg) by IV bolus and continuous IV infusion. After 60 min of treatment, the shed blood was returned. Survival was monitored for 72 h. Both dose levels resulted in a significant increase in MABP and total peripheral resistance over NS during the infusion period but heart rate, cardiac output, and left ventricular contractility were similar for all groups. Survival at 72 h was also similar for the three groups. Ibuprofen treatment, while increasing MABP and total peripheral vascular resistance did not seem to alter cardiac function or improve survival when compared to NS in this model of hypovolemic shock.

UI	MeSH Term	Description	Entries
D007052	Ibuprofen	A non-steroidal anti-inflammatory agent with analgesic, antipyretic, and anti-inflammatory properties	Advil,Benzeneacetic Acid, alpha-methyl-4-(2-methylpropyl)- trimethylsilyl ester,Brufen,Ibumetin,Ibuprofen, (+-)-Isomer,Ibuprofen, (R)-Isomer,Ibuprofen, (S)-Isomer,Ibuprofen, Aluminum Salt,Ibuprofen, Calcium Salt,Ibuprofen, Copper (2+) Salt,Ibuprofen, Magnesium Salt,Ibuprofen, Potassium Salt,Ibuprofen, Sodium Salt,Ibuprofen, Zinc Salt,Ibuprofen-Zinc,Motrin,Nuprin,Rufen,Salprofen,Trauma-Dolgit Gel,alpha-Methyl-4-(2-methylpropyl)benzeneacetic Acid,Ibuprofen Zinc,Trauma Dolgit Gel
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012769	Shock	A pathological condition manifested by failure to perfuse or oxygenate vital organs.	Circulatory Collapse,Circulatory Failure,Hypovolemic Shock,Collapse, Circulatory,Failure, Circulatory,Shock, Hypovolemic
D014655	Vascular Resistance	The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.	Peripheral Resistance,Total Peripheral Resistance,Pulmonary Vascular Resistance,Systemic Vascular Resistance,Peripheral Resistance, Total,Resistance, Peripheral,Resistance, Pulmonary Vascular,Resistance, Systemic Vascular,Resistance, Total Peripheral,Resistance, Vascular,Vascular Resistance, Pulmonary,Vascular Resistance, Systemic