It is well established that a variety of physical distancing measures are invaluable as part of the overall response to pandemics. COVID-19 is the most recent such pandemic, a respiratory disease transmitted through interaction, necessitating steps to minimize or eliminate the potential for exposure. Of course, this is driven by a desire to keep the economy moving, allow for social activity, continue education, support the livelihoods of individuals, etc. Regional science and supporting analytics have an important role in managing activity through the development and application of methods that enable spatial interaction that mitigates transmission. This paper details methods to plan for physical distancing at micro-scales, enabling the return of social, economic, entertainment, etc. activities. Geographic information systems combined with spatial optimization offers important spatial coronametrics for the mitigation of risk in disease transmission. Applications detailing office space occupancy and travel along with room seating are highlighted.