BIOMAT Database Logo BIOMAT Database Logo

RACK1 may participate in placental development at mid-gestation via regulating trophoblast cell proliferation and migration in pigs. 2023

Zhimin Wu, and Guangling Hu, and Ting Gong, and Qun Hu, and Linjun Hong, and Yiyu Zhang, and Zheng Ao
Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Ministry of Education, College of Animal Science, Guizhou University, Guiyang, China.

Intrauterine growth restriction (IUGR) is a severe complication in swine production. Placental insufficiency is responsible for inadequate fetal growth, but the specific etiology of placental dysfunction-induced IUGR in pigs remains poorly understood. In this work, placenta samples supplying the lightest weight (LW) and mean weight (MW) pig fetuses in the litter at Day 65 (D65) of gestation were collected, and the relationship between fetal growth and placental morphologies and functions was investigated using histomorphological analysis, RNA sequencing, quantitative polymerase chain reaction, and in vitro experiment in LW and MW placentas. Results showed that the folded structure of the epithelial bilayer of LW placentas followed a poor and incomplete development compared with that of MW placentas. A total of 654 differentially expressed genes (DEGs) were screened out between the LW and MW placentas, and the gene encodes receptor for activated C kinase 1 (RACK1) was found to be downregulated in LW placentas. The DEGs were mainly enriched in translation, ribosome, protein synthesis, and mammalian target of rapamycin (mTOR) signaling pathway according to gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. In vitro experiments indicated that the decreased RACK1 in LW placentas may be involved in abnormal development of placental folds (PFs) by inhibiting the proliferation and migration of porcine trophoblast cells. Taken together, these results revealed that RACK1 may be a vital regulator in the development of PFs via regulating trophoblast cell proliferation and migration in pigs.

UI MeSH Term Description Entries
D008322 Mammals Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young. Mammalia,Mammal
D009363 Neoplasm Proteins Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm. Proteins, Neoplasm
D010920 Placenta A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES). Placentoma, Normal,Placentome,Placentas,Placentomes
D010929 Placentation The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus. Hemochorial Placental Development,Hemochorial Placentation,Placental Development,Placental Development, Hemochorial,Placentation, Hemochorial
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D005317 Fetal Growth Retardation Failure of a FETUS to attain expected GROWTH. Growth Retardation, Intrauterine,Intrauterine Growth Retardation,Fetal Growth Restriction,Intrauterine Growth Restriction
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000075370 Receptors for Activated C Kinase Receptors for PROTEIN KINASE C that consist of seven WD40 REPEATS. They function in a wide variety of cellular and physiologic processes including the assembly of signaling complexes, protein translation, cell growth and proliferation, APOPTOSIS, and MUSCARINIC RECEPTOR transport. RACK1 depends on protein kinase C activity to translocate from the perinuclear region to the cell periphery and associates with the plasma membrane through interactions with KERATIN-1 and INTEGRIN BETA-1. GNB2-RS1 Protein,GNB2L1 Protein,Protein Kinase C Receptor,Protein Kinase C Receptors,RACK1 Protein,Receptor for Activated C Kinase,Receptor of Activated C Kinase 1,Receptor, Protein Kinase C,GNB2 RS1 Protein
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Zhimin Wu, and Guangling Hu, and Ting Gong, and Qun Hu, and Linjun Hong, and Yiyu Zhang, and Zheng Ao
Interleukin-10 may participate in regulating trophoblast invasion in human placentae throughout gestation.
July 2008, American journal of reproductive immunology (New York, N.Y. : 1989),
Zhimin Wu, and Guangling Hu, and Ting Gong, and Qun Hu, and Linjun Hong, and Yiyu Zhang, and Zheng Ao
Trophoblast Cell Proliferation and Apoptosis in Placental Development During Early Gestation Period in Rats.
October 2015, Analytical and quantitative cytopathology and histopathology,
Zhimin Wu, and Guangling Hu, and Ting Gong, and Qun Hu, and Linjun Hong, and Yiyu Zhang, and Zheng Ao
HAI-1 regulates placental folds development by influencing trophoblast cell proliferation and invasion in pigs.
July 2020, Gene,
Zhimin Wu, and Guangling Hu, and Ting Gong, and Qun Hu, and Linjun Hong, and Yiyu Zhang, and Zheng Ao
Circ_0111277 suppresses trophoblast cell proliferation, angiogenesis, migration, invasion and EMT via regulating miR-188-3p/GRHL2 axis.
March 2023, American journal of reproductive immunology (New York, N.Y. : 1989),
Zhimin Wu, and Guangling Hu, and Ting Gong, and Qun Hu, and Linjun Hong, and Yiyu Zhang, and Zheng Ao
E-cadherin and ZEB2 modulate trophoblast cell differentiation during placental development in pigs.
December 2017, Reproduction (Cambridge, England),
Zhimin Wu, and Guangling Hu, and Ting Gong, and Qun Hu, and Linjun Hong, and Yiyu Zhang, and Zheng Ao
Cell-cell-communication during placental development and possible implications for trophoblast proliferation and differentiation.
January 2000, Placenta,
Zhimin Wu, and Guangling Hu, and Ting Gong, and Qun Hu, and Linjun Hong, and Yiyu Zhang, and Zheng Ao
miR-1227-3p participates in the development of fetal growth restriction via regulating trophoblast cell proliferation and apoptosis.
April 2022, Scientific reports,
Zhimin Wu, and Guangling Hu, and Ting Gong, and Qun Hu, and Linjun Hong, and Yiyu Zhang, and Zheng Ao
RACK1 downregulation suppresses migration and proliferation of neuroblastoma cell lines.
May 2012, Oncology reports,
Zhimin Wu, and Guangling Hu, and Ting Gong, and Qun Hu, and Linjun Hong, and Yiyu Zhang, and Zheng Ao
Placental metabolism of cortisol at mid- and late gestation in swine.
December 1995, Biology of reproduction,
Zhimin Wu, and Guangling Hu, and Ting Gong, and Qun Hu, and Linjun Hong, and Yiyu Zhang, and Zheng Ao
The Increased lncRNA MIR503HG in Preeclampsia Modulated Trophoblast Cell Proliferation, Invasion, and Migration via Regulating Matrix Metalloproteinases and NF-κB Signaling.
January 2019, Disease markers,
Copied contents to your clipboard!