Synthesis of fused bis-indazoles/indazoles via a one-pot sequential strategy. 2023

Kishan Gugulothu, and Ramanna Jatoth, and Peramalla Edukondalu, and Anusha Vanga, and Raghavender Matta, and K Shiva Kumar
Department of Chemistry, Osmania University, Hyderabad-500 007, India.

We report here an efficient synthesis of fused bis-indazoles/indazoles via a one-pot sequential strategy starting from o-azido aldehydes and amines. This novel method involves the sequential formation of 2H-indazole followed by a Pd-catalyzed intramolecular cross-dehydrogenative coupling reaction. Overall, this one-pot sequential reaction involved the formation of new five bonds, resulting in the formation of three heterocyclic rings.

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