The solid surfaces with different profile levels impact the liquid-solid contact nature and hence wetting characteristics, showing a vital role in liquid droplets' mobility and dynamic behaviors. Therefore, engineering nanostructured features ultimately enables tuning and controlling the dynamic motion of droplets. In this study, we demonstrate an approach to manipulate nanodroplets' motion behaviors in contact with a surface through tailoring the surface morphological profile. By tracking the trajectories of water molecules at the interface, we find that the motions of a nanodroplet subjected to different levels of lateral force reveal various modes that are identified as creeping, rolling, and jumping motions. Interestingly, the elastic deformation of the droplet and sudden changes in the receding contact angle provide the mechanistic origin for droplet jumping. Guided by computational simulations, a regime map delineating the droplet motion modes with surface profile levels and applied forces is constructed, providing a design strategy for controlling droplet motions via surface engineering.