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Cobalt(II)-Catalyzed C(sp3 )-C(sp3 ) Coupling for the Direct Stereoselective Synthesis of 2-Deoxy-C-Glycosides from Glycals. 2023

Mingjie Zeng, and Changyue Yu, and Yibing Wang, and Jingjing Wang, and Jiang Wang, and Hong Liu
China Pharmaceutical University, 639 Longmian Avenue, Jiangning District, Nanjing, 211198, China.

We report a ligand-controlled CoII -catalyzed C(sp3 )-C(sp3 ) coupling hydroalkylation for direct and β-selective synthesis of 2-deoxy-C-glycosides from glycals. This reaction proceeds by a radical pathway for alkyl halide activation and is β-selective through ligand control. This approach may inspire the development of further stereoselective coupling reactions with potential application in the field of carbohydrates.

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