-transparent.png){kind=logo}
S2k Guideline - Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) - Update 2022. 2023
Jürgen C Becker, and
Ambros J Beer, and
Viola K DeTemple, and
Thomas Eigentler, and
Michael Flaig, and
Thilo Gambichler, and
Stephan Grabbe, and
Ulrike Höller, and
Bernhard Klumpp, and
Stephan Lang, and
Claudia Pföhler, and
Christian Posch, and
Vikas Prasad, and
Peter Schlattmann, and
Sylke Schneider-Burrus, and
Jan Ter-Nedden, and
Patrick Terheyden, and
Kai Thoms, and
Dirk Vordermark, and
Selma Ugurel
Translational Skin Cancer Research (TSCR), Deutsches Konsortium für translationale Krebsforschung (DKTK), Partnerstandort Essen, Department of Dermatology, University Hospital Essen, German Cancer Research Center (DKFZ), Heidelberg.
Merkel cell carcinoma (MCC, ICD-O M8247/3) is a rare, malignant, primary skin tumor with epithelial and neuroendocrine differentiation. The tumor cells share many morphologic, immunohistochemical, and ultrastructural features with cutaneous Merkel cells. Nevertheless, the cell of origin of MCC is unclear. MCC appears clinically as a reddish to purple spherical tumor with a smooth, shiny surface and a soft to turgid, elastic consistency, usually showing rapid growth. Spontaneous and often complete regressions of the tumor are observed. These likely immunologically-mediated regressions explain the cases in which only lymph node or distant metastases are found at the time of initial diagnosis and why the tumor responds very well to immunomodulatory therapies even at advanced stages. Due to its aggressiveness, the usually given indication for sentinel lymph node biopsy, the indication of adjuvant therapies to be evaluated, as well as the complexity of the necessary diagnostics, clinical management should already be determined by an interdisciplinary tumor board at the time of initial diagnosis.
Related Publications
Jürgen C Becker, and
Ambros J Beer, and
Viola K DeTemple, and
Thomas Eigentler, and
Michael Flaig, and
Thilo Gambichler, and
Stephan Grabbe, and
Ulrike Höller, and
Bernhard Klumpp, and
Stephan Lang, and
Claudia Pföhler, and
Christian Posch, and
Vikas Prasad, and
Peter Schlattmann, and
Sylke Schneider-Burrus, and
Jan Ter-Nedden, and
Patrick Terheyden, and
Kai Thoms, and
Dirk Vordermark, and
Selma Ugurel
May 2019,
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG,
Jürgen C Becker, and
Ambros J Beer, and
Viola K DeTemple, and
Thomas Eigentler, and
Michael Flaig, and
Thilo Gambichler, and
Stephan Grabbe, and
Ulrike Höller, and
Bernhard Klumpp, and
Stephan Lang, and
Claudia Pföhler, and
Christian Posch, and
Vikas Prasad, and
Peter Schlattmann, and
Sylke Schneider-Burrus, and
Jan Ter-Nedden, and
Patrick Terheyden, and
Kai Thoms, and
Dirk Vordermark, and
Selma Ugurel
June 2006,
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG,
Jürgen C Becker, and
Ambros J Beer, and
Viola K DeTemple, and
Thomas Eigentler, and
Michael Flaig, and
Thilo Gambichler, and
Stephan Grabbe, and
Ulrike Höller, and
Bernhard Klumpp, and
Stephan Lang, and
Claudia Pföhler, and
Christian Posch, and
Vikas Prasad, and
Peter Schlattmann, and
Sylke Schneider-Burrus, and
Jan Ter-Nedden, and
Patrick Terheyden, and
Kai Thoms, and
Dirk Vordermark, and
Selma Ugurel
June 2001,
American journal of clinical pathology,
Jürgen C Becker, and
Ambros J Beer, and
Viola K DeTemple, and
Thomas Eigentler, and
Michael Flaig, and
Thilo Gambichler, and
Stephan Grabbe, and
Ulrike Höller, and
Bernhard Klumpp, and
Stephan Lang, and
Claudia Pföhler, and
Christian Posch, and
Vikas Prasad, and
Peter Schlattmann, and
Sylke Schneider-Burrus, and
Jan Ter-Nedden, and
Patrick Terheyden, and
Kai Thoms, and
Dirk Vordermark, and
Selma Ugurel
April 1982,
The American journal of surgical pathology,
Jürgen C Becker, and
Ambros J Beer, and
Viola K DeTemple, and
Thomas Eigentler, and
Michael Flaig, and
Thilo Gambichler, and
Stephan Grabbe, and
Ulrike Höller, and
Bernhard Klumpp, and
Stephan Lang, and
Claudia Pföhler, and
Christian Posch, and
Vikas Prasad, and
Peter Schlattmann, and
Sylke Schneider-Burrus, and
Jan Ter-Nedden, and
Patrick Terheyden, and
Kai Thoms, and
Dirk Vordermark, and
Selma Ugurel
February 1987,
Zeitschrift fur Hautkrankheiten,
Jürgen C Becker, and
Ambros J Beer, and
Viola K DeTemple, and
Thomas Eigentler, and
Michael Flaig, and
Thilo Gambichler, and
Stephan Grabbe, and
Ulrike Höller, and
Bernhard Klumpp, and
Stephan Lang, and
Claudia Pföhler, and
Christian Posch, and
Vikas Prasad, and
Peter Schlattmann, and
Sylke Schneider-Burrus, and
Jan Ter-Nedden, and
Patrick Terheyden, and
Kai Thoms, and
Dirk Vordermark, and
Selma Ugurel
March 1984,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
Jürgen C Becker, and
Ambros J Beer, and
Viola K DeTemple, and
Thomas Eigentler, and
Michael Flaig, and
Thilo Gambichler, and
Stephan Grabbe, and
Ulrike Höller, and
Bernhard Klumpp, and
Stephan Lang, and
Claudia Pföhler, and
Christian Posch, and
Vikas Prasad, and
Peter Schlattmann, and
Sylke Schneider-Burrus, and
Jan Ter-Nedden, and
Patrick Terheyden, and
Kai Thoms, and
Dirk Vordermark, and
Selma Ugurel
August 2022,
European journal of cancer (Oxford, England : 1990),
Jürgen C Becker, and
Ambros J Beer, and
Viola K DeTemple, and
Thomas Eigentler, and
Michael Flaig, and
Thilo Gambichler, and
Stephan Grabbe, and
Ulrike Höller, and
Bernhard Klumpp, and
Stephan Lang, and
Claudia Pföhler, and
Christian Posch, and
Vikas Prasad, and
Peter Schlattmann, and
Sylke Schneider-Burrus, and
Jan Ter-Nedden, and
Patrick Terheyden, and
Kai Thoms, and
Dirk Vordermark, and
Selma Ugurel
January 1982,
Schweizerische medizinische Wochenschrift,
Jürgen C Becker, and
Ambros J Beer, and
Viola K DeTemple, and
Thomas Eigentler, and
Michael Flaig, and
Thilo Gambichler, and
Stephan Grabbe, and
Ulrike Höller, and
Bernhard Klumpp, and
Stephan Lang, and
Claudia Pföhler, and
Christian Posch, and
Vikas Prasad, and
Peter Schlattmann, and
Sylke Schneider-Burrus, and
Jan Ter-Nedden, and
Patrick Terheyden, and
Kai Thoms, and
Dirk Vordermark, and
Selma Ugurel
June 2013,
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG,
Jürgen C Becker, and
Ambros J Beer, and
Viola K DeTemple, and
Thomas Eigentler, and
Michael Flaig, and
Thilo Gambichler, and
Stephan Grabbe, and
Ulrike Höller, and
Bernhard Klumpp, and
Stephan Lang, and
Claudia Pföhler, and
Christian Posch, and
Vikas Prasad, and
Peter Schlattmann, and
Sylke Schneider-Burrus, and
Jan Ter-Nedden, and
Patrick Terheyden, and
Kai Thoms, and
Dirk Vordermark, and
Selma Ugurel
January 1989,
Deutsche medizinische Wochenschrift (1946),
