Biomaterial Database

The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes. 2023

Sara J C Gosline, and Doo Nam Kim, and Paritosh Pande, and Dennis G Thomas, and Lisa Truong, and Peter Hoffman, and Michael Barton, and Joseph Loftus, and Addy Moran, and Shawn Hampton, and Scott Dowson, and Lyndsey Franklin, and David Degnan, and Lindsey Anderson, and Anne Thessen, and Robyn L Tanguay, and Kim A Anderson, and Katrina M Waters

Pacific Northwest National Laboratory, Richland, WA, USA.

The OSU/PNNL Superfund Research Program (SRP) represents a longstanding collaboration to quantify Polycyclic Aromatic Hydrocarbons (PAHs) at various superfund sites in the Pacific Northwest and assess their potential impact on human health. To link the chemical measurements to biological activity, we describe the use of the zebrafish as a high-throughput developmental toxicity model that provides quantitative measurements of the exposure to chemicals. Toward this end, we have linked over 150 PAHs found at Superfund sites to the effect of these same chemicals in zebrafish, creating a rich dataset that links environmental exposure to biological response. To quantify this response, we have implemented a dose-response modelling pipeline to calculate benchmark dose parameters which enable potency comparison across over 500 chemicals and 12 of the phenotypes measured in zebrafish. We provide a rich dataset for download and analysis as well as a web portal that provides public access to this dataset via an interactive web site designed to support exploration and re-use of these data by the scientific community at http://srp.pnnl.gov .

UI	MeSH Term	Description	Entries
D011084	Polycyclic Aromatic Hydrocarbons	Aromatic hydrocarbons that contain extended fused-ring structures.	Polycyclic Aromatic Hydrocarbon,Polycyclic Hydrocarbons, Aromatic,Polynuclear Aromatic Hydrocarbon,Polynuclear Aromatic Hydrocarbons,Aromatic Hydrocarbon, Polycyclic,Aromatic Hydrocarbon, Polynuclear,Aromatic Hydrocarbons, Polycyclic,Aromatic Hydrocarbons, Polynuclear,Aromatic Polycyclic Hydrocarbons,Hydrocarbon, Polycyclic Aromatic,Hydrocarbon, Polynuclear Aromatic,Hydrocarbons, Aromatic Polycyclic,Hydrocarbons, Polycyclic Aromatic,Hydrocarbons, Polynuclear Aromatic
D004781	Environmental Exposure	The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.	Exposure, Environmental,Environmental Exposures,Exposures, Environmental
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015027	Zebrafish	An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. Zebrafish is a model organism for drug assay and cancer research.	Brachydanio rerio,Danio rerio,B. rerio,D. rerio,Zebra Fish,Zebra Fishes,Zebra danio,Zebrafishes,D. rerios,Fishes, Zebra,Zebra danios,danio, Zebra
D015205	Northwestern United States	The geographic area of the northwestern region of the United States. The states usually included in this region are Idaho, Montana, Oregon, Washington, and Wyoming.	Northwest U.S.,Pacific Northwest,Northwest US
D015386	Hazardous Substances	Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.	Biohazard,Hazardous Chemical,Hazardous Chemicals,Hazardous Material,Hazardous Materials,Hazardous Substance,Toxic Environmental Substance,Toxic Substances, Environmental,Biohazards,Chemicals, Hazardous,Environmental Substances, Toxic,Toxic Environmental Substances,Chemical, Hazardous,Environmental Substance, Toxic,Environmental Toxic Substances,Material, Hazardous,Materials, Hazardous,Substance, Hazardous,Substance, Toxic Environmental,Substances, Environmental Toxic,Substances, Hazardous,Substances, Toxic Environmental