BIOMAT Database Logo BIOMAT Database Logo

Solving the insoluble: calciprotein particles mediate bulk mineral transport. 2023

Willi Jahnen-Dechent, and Andreas Pasch
Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Hospital, Aachen, Germany. Electronic address: willi.jahnen@rwth-aachen.de.

Protein mineral complexes, or calciprotein particles, are formed by calcium, phosphate, and the plasma protein fetuin-A. Crystalline calciprotein particles cause soft tissue calcification, oxidative stress, and inflammation, all well-known complications in chronic kidney disease. The T50 calcification propensity test measures how long it takes for amorphous calciprotein particles to crystallize. A study in this volume demonstrates remarkably low calcification propensity in cord blood, despite high mineral concentration. This hints to previously unidentified calcification inhibitors.

UI MeSH Term Description Entries
D008903 Minerals Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Mineral
D002114 Calcinosis Pathologic deposition of calcium salts in tissues. Calcification, Pathologic,Calcinosis, Tumoral,Microcalcification,Microcalcinosis,Pathologic Calcification,Calcinoses,Calcinoses, Tumoral,Microcalcifications,Microcalcinoses,Tumoral Calcinoses,Tumoral Calcinosis
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D051436 Renal Insufficiency, Chronic Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002) Kidney Insufficiency, Chronic,Chronic Kidney Diseases,Chronic Kidney Insufficiency,Chronic Renal Diseases,Chronic Renal Insufficiency,Chronic Kidney Disease,Chronic Kidney Insufficiencies,Chronic Renal Disease,Chronic Renal Insufficiencies,Disease, Chronic Kidney,Disease, Chronic Renal,Diseases, Chronic Kidney,Diseases, Chronic Renal,Kidney Disease, Chronic,Kidney Diseases, Chronic,Kidney Insufficiencies, Chronic,Renal Disease, Chronic,Renal Diseases, Chronic,Renal Insufficiencies, Chronic
D060749 alpha-2-HS-Glycoprotein A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. It plays a major role in preventing CALCIUM precipitation in the BLOOD. alpha2 Heremans-Schmid Glycoprotein,AHSG Protein,Fetuin-A,alpha(2) HS Glycoprotein,alpha-2HS Glycoprotein,alpha2HS Glycoprotein,Fetuin A,alpha 2 HS Glycoprotein,alpha 2HS Glycoprotein

Related Publications

Willi Jahnen-Dechent, and Andreas Pasch
Calciprotein particles: mineral behaving badly?
July 2020, Current opinion in nephrology and hypertension,
Willi Jahnen-Dechent, and Andreas Pasch
Calciprotein Particles: Balancing Mineral Homeostasis and Vascular Pathology.
May 2021, Arteriosclerosis, thrombosis, and vascular biology,
Willi Jahnen-Dechent, and Andreas Pasch
Fetuin-A-containing calciprotein particles reduce mineral stress in the macrophage.
January 2013, PloS one,
Willi Jahnen-Dechent, and Andreas Pasch
Calciprotein particles: A mineral biomarker in need of better measurement.
June 2020, Atherosclerosis,
Willi Jahnen-Dechent, and Andreas Pasch
Fetuin-A-containing calciprotein particles in mineral trafficking and vascular disease.
October 2016, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Willi Jahnen-Dechent, and Andreas Pasch
Nature's remedy to phosphate woes: calciprotein particles regulate systemic mineral metabolism.
April 2020, Kidney international,
Willi Jahnen-Dechent, and Andreas Pasch
Solving the insoluble.
January 2006, Journal of Alzheimer's disease : JAD,
Willi Jahnen-Dechent, and Andreas Pasch
Biological and Clinical Effects of Calciprotein Particles on Chronic Kidney Disease-Mineral and Bone Disorder.
January 2018, International journal of endocrinology,
Willi Jahnen-Dechent, and Andreas Pasch
Calciprotein Particles Cause Endothelial Dysfunction under Flow.
November 2020, International journal of molecular sciences,
Willi Jahnen-Dechent, and Andreas Pasch
Biochemical transformation of calciprotein particles in uraemia.
May 2018, Bone,
Copied contents to your clipboard!