Enzyme assays of major blood lipid parameters detected no differences between peripheral venous blood specimens of normal subjects and functional cardiologic patients, nor between peripheral and central flow specimens of patients with neurocirculatory dystonia. Alpha cholesterol was typically decreased in all types of coronary disease, the decrease being particularly marked in central cardiac flow. Chronic coronary disease is associated with a rise of total cholesterol, its atherogenic fractions, the atherogenic coefficient and blood triglycerides, as compared to the respective parameters of functional cardiac patients. Acute and subacute coronary disease is associated with decreased blood lipid values, as compared to chronic coronary disease. Blood lipid phenotyping and secondary preventive procedures should rather be done in the absence of aggravations.