BIOMAT Database Logo BIOMAT Database Logo

Metabolic activation of 3-methylcholanthrene: mutagenic and transforming activities of the 9,10-dihydrodiol. 1978

C Malaveille, and H Bartsch, and H Marquardt, and S Baker, and B Tierney, and A Hewer, and P L Grover, and P Sims

UI MeSH Term Description Entries
D008748 Methylcholanthrene A carcinogen that is often used in experimental cancer studies. 20-Methylcholanthrene,3-Methylcholanthrene,20 Methylcholanthrene,3 Methylcholanthrene
D008862 Microsomes, Liver Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough. Liver Microsomes,Liver Microsome,Microsome, Liver
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002471 Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. Neoplastic Transformation, Cell,Neoplastic Cell Transformation,Transformation, Neoplastic Cell,Tumorigenic Transformation,Cell Neoplastic Transformation,Cell Neoplastic Transformations,Cell Transformations, Neoplastic,Neoplastic Cell Transformations,Neoplastic Transformations, Cell,Transformation, Cell Neoplastic,Transformation, Tumorigenic,Transformations, Cell Neoplastic,Transformations, Neoplastic Cell,Transformations, Tumorigenic,Tumorigenic Transformations
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D001711 Biotransformation The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D012486 Salmonella typhimurium A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER. Salmonella typhimurium LT2
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships

Related Publications

C Malaveille, and H Bartsch, and H Marquardt, and S Baker, and B Tierney, and A Hewer, and P L Grover, and P Sims
Tumor-initiating activity of the 9,10-dihydrodiol- and 9,10-dihydrodiol-7,8-epoxide of 3-methylcholanthrene in SENCAR mice.
September 1985, Cancer letters,
C Malaveille, and H Bartsch, and H Marquardt, and S Baker, and B Tierney, and A Hewer, and P L Grover, and P Sims
The identification of 3-methylcholanthrene-9,10-dihydrodiol as an intermediate in the binding of 3-methylcholanthrene to DNA in cells in culture.
March 1978, Chemico-biological interactions,
C Malaveille, and H Bartsch, and H Marquardt, and S Baker, and B Tierney, and A Hewer, and P L Grover, and P Sims
Metabolic formation of 1,9,10-trihydroxy-9,10-dihydro-3-methylcholanthrene: a potential proximate carcinogen from 3-methylcholanthrene.
January 1978, Journal of the American Chemical Society,
C Malaveille, and H Bartsch, and H Marquardt, and S Baker, and B Tierney, and A Hewer, and P L Grover, and P Sims
Metabolic activation of 3-methylcholanthrene and its metabolites to products mutagenic to bacterial and mammalian cells.
October 1978, Cancer research,
C Malaveille, and H Bartsch, and H Marquardt, and S Baker, and B Tierney, and A Hewer, and P L Grover, and P Sims
Intrinsic mutagenicity and electrophilicity of 1-sulfooxy-3-methylcholanthrene: implications for metabolic activation of the carcinogen 3-methylcholanthrene.
November 1995, Biochemistry and molecular biology international,
C Malaveille, and H Bartsch, and H Marquardt, and S Baker, and B Tierney, and A Hewer, and P L Grover, and P Sims
9,10-Dihydroxy-9,10-dihydro-3-methylcholanthrene-2-one: a principal metabolite of the potent carcinogen 3-methylcholanthrene-2-one by rat liver microsomes.
April 1990, Carcinogenesis,
C Malaveille, and H Bartsch, and H Marquardt, and S Baker, and B Tierney, and A Hewer, and P L Grover, and P Sims
Metabolic activation of benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide to protein-binding products and the inhibitory effect of glutathione and cysteine.
February 1984, Carcinogenesis,
C Malaveille, and H Bartsch, and H Marquardt, and S Baker, and B Tierney, and A Hewer, and P L Grover, and P Sims
Are transforming and mutagenic activities of oncogenic papovaviruses correlated?
January 1983, Archiv fur Geschwulstforschung,
C Malaveille, and H Bartsch, and H Marquardt, and S Baker, and B Tierney, and A Hewer, and P L Grover, and P Sims
Metabolic activation of trp-P-2, a mutagenic amine from tryptophan-pyrolysate, by liver microsomes from 3-methylcholanthrene-responsive and non-responsive mice.
January 1980, Xenobiotica; the fate of foreign compounds in biological systems,
C Malaveille, and H Bartsch, and H Marquardt, and S Baker, and B Tierney, and A Hewer, and P L Grover, and P Sims
Multiple metabolic pathways for the mutagenic activation of 3-nitrobenzo[a]pyrene.
August 1985, Carcinogenesis,
Copied contents to your clipboard!