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Prolactin stimulates a hepatotrophic response similar to that caused by phorbol esters or partial hepatectomy in rats. Since phorbol esters, which activate protein kinase C, mimic prolactin action in liver, the relationship between prolactin administration and subsequent hepatic protein kinase C translocation was assessed. Prolactin administration rapidly stimulated a 4-fold elevation of membrane protein kinase C activity. The effect of prolactin on hepatic protein kinase C was specific for lactogenic hormones but could be duplicated by phorbol esters. Further, an increase in serum prolactin was demonstrated subsequent to partial hepatectomy and preceding hepatic protein kinase C translocation. Therefore, translocation of hepatic protein kinase C appears important for hepatic proliferation in response to prolactin administration and to partial hepatectomy.
A R Buckley, and
C W Putnam, and
R Evans, and
H E Laird, and
G N Shah, and
D W Montgomery, and
D H Russell
June 1994,
Annals of the New York Academy of Sciences,
A R Buckley, and
C W Putnam, and
R Evans, and
H E Laird, and
G N Shah, and
D W Montgomery, and
D H Russell
February 1996,
Biochemistry and molecular biology international,
A R Buckley, and
C W Putnam, and
R Evans, and
H E Laird, and
G N Shah, and
D W Montgomery, and
D H Russell
July 1985,
Biochemical and biophysical research communications,
A R Buckley, and
C W Putnam, and
R Evans, and
H E Laird, and
G N Shah, and
D W Montgomery, and
D H Russell
March 1993,
Journal of neurochemistry,
A R Buckley, and
C W Putnam, and
R Evans, and
H E Laird, and
G N Shah, and
D W Montgomery, and
D H Russell
May 1989,
Biochemical and biophysical research communications,
A R Buckley, and
C W Putnam, and
R Evans, and
H E Laird, and
G N Shah, and
D W Montgomery, and
D H Russell
October 1983,
Infection and immunity,
A R Buckley, and
C W Putnam, and
R Evans, and
H E Laird, and
G N Shah, and
D W Montgomery, and
D H Russell
December 1987,
FEBS letters,
A R Buckley, and
C W Putnam, and
R Evans, and
H E Laird, and
G N Shah, and
D W Montgomery, and
D H Russell
December 1993,
Nihon Geka Gakkai zasshi,
A R Buckley, and
C W Putnam, and
R Evans, and
H E Laird, and
G N Shah, and
D W Montgomery, and
D H Russell
January 2003,
Methods in molecular biology (Clifton, N.J.),
A R Buckley, and
C W Putnam, and
R Evans, and
H E Laird, and
G N Shah, and
D W Montgomery, and
D H Russell
May 1995,
Journal of cellular physiology,
