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To aid in evaluating the functional significance of various domains of the hepatocyte plasma membrane, we have developed monoclonal antibodies that react with three different antigens on the surface of rat hepatocytes. One antigen is present on the sinusoidal-lateral plasma membrane but is absent from the bile canalicular membrane. On the basis of apparent molecular weight and ability to bind a desialylated glycoprotein, this antigen may be the asialoglycoprotein receptor. It was also identified immunocytochemically on the sinusoidal-lateral plasma membrane of human hepatocytes. The second antigen is present only on the bile canalicular membrane, whereas the third is present on the entire cell surface of rat hepatocytes. Our monoclonal antibodies may be useful in investigations of the sorting mechanisms of hepatocyte membrane proteins and the pathogenesis of certain liver diseases.
M Mizuno, and
G Yamada, and
T Sugiyama, and
J M Vierling, and
W R Brown
January 1988,
Avian pathology : journal of the W.V.P.A,
M Mizuno, and
G Yamada, and
T Sugiyama, and
J M Vierling, and
W R Brown
June 1984,
Immunology,
M Mizuno, and
G Yamada, and
T Sugiyama, and
J M Vierling, and
W R Brown
September 1984,
Nihon Jinzo Gakkai shi,
M Mizuno, and
G Yamada, and
T Sugiyama, and
J M Vierling, and
W R Brown
January 1992,
Acta anatomica,
M Mizuno, and
G Yamada, and
T Sugiyama, and
J M Vierling, and
W R Brown
August 1991,
Cell structure and function,
M Mizuno, and
G Yamada, and
T Sugiyama, and
J M Vierling, and
W R Brown
August 1993,
Immunobiology,
M Mizuno, and
G Yamada, and
T Sugiyama, and
J M Vierling, and
W R Brown
December 1982,
European journal of biochemistry,
M Mizuno, and
G Yamada, and
T Sugiyama, and
J M Vierling, and
W R Brown
December 2001,
Immunological reviews,
M Mizuno, and
G Yamada, and
T Sugiyama, and
J M Vierling, and
W R Brown
November 1988,
Acta endocrinologica,
M Mizuno, and
G Yamada, and
T Sugiyama, and
J M Vierling, and
W R Brown
June 1981,
Transplantation proceedings,
