BIOMAT Database Logo BIOMAT Database Logo

Perspective insights of small molecules, phytoconstituents and biologics in the management of psoriasis: A focus on targeting major inflammatory cytokine pathways. 2023

Husna Kadagothy, and Shweta Nene, and Etikala Amulya, and Ganesh Vambhurkar, and A N Rajalakshmi, and Dharmendra Kumar Khatri, and Shashi Bala Singh, and Saurabh Srivastava
Department of Pharmaceutics, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India.

Psoriasis is an enduring, pruritic and papulosquamous skin ailment that poses a significant burden on public health. It is mainly characterized by hyperkeratosis, acanthosis, parakeratosis, scaly and erythematous plaques. Biomarkers like interleukin-17, interleukin-12 and -23 and tumor necrosis factor-α serve as key drivers of psoriatic pathogenesis. Triggered release of pro-inflammatory cytokines from various up-regulated pathways leads to psoriatic inflammation. Several target moieties like biologics, small molecules and herbal moieties play a fundamental role in the repression of pathogenesis of psoriasis. Biologics and small molecules engaged in the management of psoriasis have been emphasized in detail. An insight into nano-carrier interventions on herbal moieties and clinical aspects of psoriasis are also highlighted. This review emphasizes various pathological targets involved in psoriasis.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D011565 Psoriasis A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. Palmoplantaris Pustulosis,Pustular Psoriasis of Palms and Soles,Pustulosis Palmaris et Plantaris,Pustulosis of Palms and Soles,Psoriases
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001688 Biological Products Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay. Biologic,Biologic Drug,Biologic Product,Biological,Biological Drug,Biological Medicine,Biological Product,Biologics,Biopharmaceutical,Natural Product,Natural Products,Biologic Drugs,Biologic Medicines,Biologic Pharmaceuticals,Biologic Products,Biological Drugs,Biological Medicines,Biologicals,Biopharmaceuticals,Products, Biological,Drug, Biologic,Drug, Biological,Drugs, Biologic,Drugs, Biological,Medicine, Biological,Medicines, Biologic,Medicines, Biological,Pharmaceuticals, Biologic,Product, Biologic,Product, Biological,Product, Natural
D012867 Skin The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D016207 Cytokines Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner. Cytokine

Related Publications

Husna Kadagothy, and Shweta Nene, and Etikala Amulya, and Ganesh Vambhurkar, and A N Rajalakshmi, and Dharmendra Kumar Khatri, and Shashi Bala Singh, and Saurabh Srivastava
Treating psoriasis in the elderly: biologics and small molecules.
December 2022, Expert opinion on biological therapy,
Husna Kadagothy, and Shweta Nene, and Etikala Amulya, and Ganesh Vambhurkar, and A N Rajalakshmi, and Dharmendra Kumar Khatri, and Shashi Bala Singh, and Saurabh Srivastava
Small Molecules and Biologics in the Treatment of Nail Psoriasis.
June 2020, Skin appendage disorders,
Husna Kadagothy, and Shweta Nene, and Etikala Amulya, and Ganesh Vambhurkar, and A N Rajalakshmi, and Dharmendra Kumar Khatri, and Shashi Bala Singh, and Saurabh Srivastava
Biologics and small molecules in patients with scalp psoriasis: a systematic review.
February 2022, The Journal of dermatological treatment,
Husna Kadagothy, and Shweta Nene, and Etikala Amulya, and Ganesh Vambhurkar, and A N Rajalakshmi, and Dharmendra Kumar Khatri, and Shashi Bala Singh, and Saurabh Srivastava
Efficacy and safety of biologics and small molecules for psoriasis in pediatric and geriatric populations. Part II: focus on elderly patients.
January 2023, Expert opinion on drug safety,
Husna Kadagothy, and Shweta Nene, and Etikala Amulya, and Ganesh Vambhurkar, and A N Rajalakshmi, and Dharmendra Kumar Khatri, and Shashi Bala Singh, and Saurabh Srivastava
Efficacy and safety of biologics and small molecules for psoriasis in pediatric and geriatric populations. Part I: focus on pediatric patients.
January 2023, Expert opinion on drug safety,
Husna Kadagothy, and Shweta Nene, and Etikala Amulya, and Ganesh Vambhurkar, and A N Rajalakshmi, and Dharmendra Kumar Khatri, and Shashi Bala Singh, and Saurabh Srivastava
Therapeutic update of biologics and small molecules for scalp psoriasis: a systematic review.
March 2021, Dermatologic therapy,
Husna Kadagothy, and Shweta Nene, and Etikala Amulya, and Ganesh Vambhurkar, and A N Rajalakshmi, and Dharmendra Kumar Khatri, and Shashi Bala Singh, and Saurabh Srivastava
Risk of Major Adverse Cardiovascular Events in Immune-Mediated Inflammatory Disorders on Biologics and Small Molecules: Network Meta-Analysis.
May 2024, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association,
Husna Kadagothy, and Shweta Nene, and Etikala Amulya, and Ganesh Vambhurkar, and A N Rajalakshmi, and Dharmendra Kumar Khatri, and Shashi Bala Singh, and Saurabh Srivastava
Model-Based Meta-Analysis in Psoriasis: A Quantitative Comparison of Biologics and Small Targeted Molecules.
January 2021, Frontiers in pharmacology,
Husna Kadagothy, and Shweta Nene, and Etikala Amulya, and Ganesh Vambhurkar, and A N Rajalakshmi, and Dharmendra Kumar Khatri, and Shashi Bala Singh, and Saurabh Srivastava
New biologics and small molecules in inflammatory bowel disease: an update.
January 2019, Therapeutic advances in gastroenterology,
Husna Kadagothy, and Shweta Nene, and Etikala Amulya, and Ganesh Vambhurkar, and A N Rajalakshmi, and Dharmendra Kumar Khatri, and Shashi Bala Singh, and Saurabh Srivastava
Targeting RNA with small molecules-A safety perspective.
January 2023, British journal of pharmacology,
Copied contents to your clipboard!