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Three-in-one self-assembled metallo-nanophotosensitizers for photodynamic/chemodynamic/chemo multimodal synergistic cancer therapy. 2023
Shuang Chao, and
Ziyan Shen, and
Jiaming Ren, and
Zhilin Zhang, and
Xiaolin Chen, and
Yuxin Pei, and
Zhichao Pei
College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China. peizc@nwafu.edu.cn.
A three-in-one self-assembled metallo-nanophotosensitizer system (NLCD) was constructed by cooperative coordination of amphiphilic L-arginine-modified photosensitizer NBS-L-Arg and DOX in the presence of Cu2+via the synergy of coordination, hydrophobic, and π-π stacking interactions. The resulting NLCD NPs possessed uniform size, well-defined nanosphere structure, and GSH-responsive ability. In vitro studies exhibited that NLCD NPs integrating photodynamic/chemodynamic/chemo multimodal therapy achieved an enhanced therapeutic effect.
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