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Lesions of basal forebrain cholinergic nuclei projecting in neocortex have recently been employed as an animal model for the cholinergic deficits in Alzheimer's disease. However, unlike Alzheimer's patients, whose deterioration appears to be progressive and irreversible, basalis lesioned rats usually recover both behaviorally and neurochemically within several months after the lesion. We now demonstrate that this recovery may be a function of the age of the rat and that cholinergic deficits re-occur in the aged rat. Choline acetyltransferase (ChAT) activity and [3H]hemicholinium-3 ([3H]HCh-3) binding are reduced in cortex ipsilateral to ibotenic acid lesions in the 12-month postlesion rat following an initial recovery to normal levels by about 3 months postlesion. The recurrence of decrease of cholinergic markers is not a consequence of a non-specific age-related decline since the activity of glutamic acid decarboxylase remains constant between 3 and 12 months postlesion.
G F Hohmann, and
G L Wenk, and
P Lowenstein, and
M E Brown, and
J T Coyle
May 1992,
Japanese journal of pharmacology,
G F Hohmann, and
G L Wenk, and
P Lowenstein, and
M E Brown, and
J T Coyle
July 1997,
Neuroreport,
G F Hohmann, and
G L Wenk, and
P Lowenstein, and
M E Brown, and
J T Coyle
September 2004,
Experimental neurology,
G F Hohmann, and
G L Wenk, and
P Lowenstein, and
M E Brown, and
J T Coyle
March 2019,
Scientific reports,
G F Hohmann, and
G L Wenk, and
P Lowenstein, and
M E Brown, and
J T Coyle
May 1988,
Brain research,
G F Hohmann, and
G L Wenk, and
P Lowenstein, and
M E Brown, and
J T Coyle
October 2013,
Neurochemical research,
G F Hohmann, and
G L Wenk, and
P Lowenstein, and
M E Brown, and
J T Coyle
September 2022,
ACS pharmacology & translational science,
G F Hohmann, and
G L Wenk, and
P Lowenstein, and
M E Brown, and
J T Coyle
November 2005,
Neuron,
G F Hohmann, and
G L Wenk, and
P Lowenstein, and
M E Brown, and
J T Coyle
January 1991,
Neuroscience letters,
G F Hohmann, and
G L Wenk, and
P Lowenstein, and
M E Brown, and
J T Coyle
October 1996,
Brain research. Developmental brain research,
