Selective syntheses of 6-substituted pyrimidine nucleosides and their interactions with uridine phosphorylase. 1987

K Felczak, and I Samulewicz, and A K Drabikowska, and T Kulikowski, and D Shugar
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa.

Several 6-substituted pyrimidine nucleosides have been prepared by condensation of an N(3)-benzyl or C(4)-methylthio pyrimidine with the appropriately blocked sugar, followed by the use of mild conditions at room temperature for removal of blocking groups. The substrate properties of these nucleosides, which are in the fixed syn conformation, have been examined in the uridine phosphorylase system.

UI MeSH Term Description Entries
D007202 Indicators and Reagents Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499) Indicator,Reagent,Reagents,Indicators,Reagents and Indicators
D007700 Kinetics The rate dynamics in chemical or physical systems.
D010430 Pentosyltransferases Enzymes of the transferase class that catalyze the transfer of a pentose group from one compound to another.
D011741 Pyrimidine Nucleosides Pyrimidines with a RIBOSE attached that can be phosphorylated to PYRIMIDINE NUCLEOTIDES. Nucleosides, Pyrimidine
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D013379 Substrate Specificity A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts. Specificities, Substrate,Specificity, Substrate,Substrate Specificities
D014543 Uridine Phosphorylase An enzyme that catalyzes the transfer of ribose from uridine to orthophosphate, forming uracil and ribose 1-phosphate. 5-Fluoro-2'-deoxyuridine Phosphorylase,5 Fluoro 2' deoxyuridine Phosphorylase,Phosphorylase, 5-Fluoro-2'-deoxyuridine,Phosphorylase, Uridine

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