Carcinogenesis Observed in the Spleens of Balb/c Mice After Head-neutron Irradiation. 2023

Yuko Kinashi, and Takushi Takata, and Yoshinori Sakurai, and Hiroki Tanaka
Institute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka, Japan kinashi.yuko.3r@kyoto-u.ac.jp kinashi@rri.kyoto-u.ac.jp.

OBJECTIVE To investigate the long-term influence of head-neutron irradiation on mice spleens, post-radiation late effects were examined in three types of mice: Balb/c and severe combined immunodeficiency (SCID) mice, which have high radio-sensitivities, and C3H mice. METHODS Neutron irradiation was performed with the neutron beam of the Kyoto University Research Reactor. Survival fractions and the change in spleen size after head-neutron irradiation were investigated in three different types of mice. Physical condition after neutron irradiation was observed for eighteen months. RESULTS The onset of primary splenic malignant lymphoma was recognized in many of the Balb/c mice 18 months after head-neutron irradiation. Eight months after head-neutron irradiation, many SCID mice developed an abscess in the part exposed to radiation and spleen swelling. The swollen spleen of SCID mice had hematopoiesis from the marrow. CONCLUSIONS Low energy head-neutron irradiation damages immune organs in radiosensitive SCID and Balb/c mice. A combination of boron neutron capture therapy and immunotherapy may be less toxic than low-energy neutron-irradiation alone.

UI MeSH Term Description Entries
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008809 Mice, Inbred C3H An inbred strain of mouse that is used as a general purpose strain in a wide variety of RESEARCH areas including CANCER; INFECTIOUS DISEASES; sensorineural, and cardiovascular biology research. Mice, C3H,Mouse, C3H,Mouse, Inbred C3H,C3H Mice,C3H Mice, Inbred,C3H Mouse,C3H Mouse, Inbred,Inbred C3H Mice,Inbred C3H Mouse
D009502 Neutrons Electrically neutral elementary particles found in all atomic nuclei except light hydrogen; the mass is equal to that of the proton and electron combined and they are unstable when isolated from the nucleus, undergoing beta decay. Slow, thermal, epithermal, and fast neutrons refer to the energy levels with which the neutrons are ejected from heavier nuclei during their decay. Neutron
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013154 Spleen An encapsulated lymphatic organ through which venous blood filters.
D016513 Mice, SCID Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice. SCID Mice,SCID-hu Mice,Severe Combined Immunodeficient Mice,Immunodeficient Mice, Severe Combined,Mouse, SCID,Mouse, SCID-hu,Mice, SCID-hu,Mouse, SCID hu,SCID Mouse,SCID hu Mice,SCID-hu Mouse
D016754 Boron Neutron Capture Therapy A technique for the treatment of neoplasms, especially gliomas and melanomas in which boron-10, an isotope, is introduced into the target cells followed by irradiation with thermal neutrons. Boron-Neutron Capture Therapy,Neutron Capture Therapy, Boron,Therapy, Boron Neutron Capture,Therapy, Boron-Neutron Capture
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D063646 Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years. Tumorigenesis,Oncogenesis,Carcinogeneses,Oncogeneses,Tumorigeneses

Related Publications

Yuko Kinashi, and Takushi Takata, and Yoshinori Sakurai, and Hiroki Tanaka
March 1983, Radiation research,
Yuko Kinashi, and Takushi Takata, and Yoshinori Sakurai, and Hiroki Tanaka
December 1977, Radiation research,
Yuko Kinashi, and Takushi Takata, and Yoshinori Sakurai, and Hiroki Tanaka
December 1990, Cancer letters,
Yuko Kinashi, and Takushi Takata, and Yoshinori Sakurai, and Hiroki Tanaka
April 1990, Tumori,
Yuko Kinashi, and Takushi Takata, and Yoshinori Sakurai, and Hiroki Tanaka
October 1987, Cancer letters,
Yuko Kinashi, and Takushi Takata, and Yoshinori Sakurai, and Hiroki Tanaka
January 1982, Carcinogenesis,
Yuko Kinashi, and Takushi Takata, and Yoshinori Sakurai, and Hiroki Tanaka
January 1975, Mechanisms of ageing and development,
Yuko Kinashi, and Takushi Takata, and Yoshinori Sakurai, and Hiroki Tanaka
July 1986, Carcinogenesis,
Yuko Kinashi, and Takushi Takata, and Yoshinori Sakurai, and Hiroki Tanaka
May 1985, Cancer research,
Yuko Kinashi, and Takushi Takata, and Yoshinori Sakurai, and Hiroki Tanaka
September 1985, Experimental hematology,
Copied contents to your clipboard!