-transparent.png){kind=logo}
Thymidine kinase, the enzyme in the pyrimidine salvage pathway, and its isozymes were examined in 10 specimens of normal mammary gland, 10 fibroadenomas and 11 adenocarcinomas in human breasts. The average thymidine kinase activities in fibroadenomas and adenocarcinomas were about 3 and 8 times that in normal mammary gland. The mammary thymidine kinase isozymes were separated into two types by diethylaminoethyl (DEAE) cellulose column chromatography. The activity of the thymidine kinase isozyme eluted with 0.1 M sodium chloride in buffer was twofold higher in fibroadenomas and fourfold higher in adenocarcinomas than that in normal tissue. In adenocarcinomas, but not fibroadenomas, the activity of the other isozyme eluted with buffer alone was increased to 22-fold that in normal tissues. As the activity of the latter isozyme was not affected by deoxycytidine triphosphate, it may be involved closely in DNA replication.
S Sakamoto, and
T Iwama, and
M Ebuchi, and
K Tsukada, and
T Sagara, and
T Kawasaki, and
S Murakami, and
N Kasahara, and
H Kudo, and
R Okamoto
January 1991,
Thyroid : official journal of the American Thyroid Association,
S Sakamoto, and
T Iwama, and
M Ebuchi, and
K Tsukada, and
T Sagara, and
T Kawasaki, and
S Murakami, and
N Kasahara, and
H Kudo, and
R Okamoto
August 1980,
Brain research,
S Sakamoto, and
T Iwama, and
M Ebuchi, and
K Tsukada, and
T Sagara, and
T Kawasaki, and
S Murakami, and
N Kasahara, and
H Kudo, and
R Okamoto
January 1975,
Progress in medical virology. Fortschritte der medizinischen Virusforschung. Progres en virologie medicale,
S Sakamoto, and
T Iwama, and
M Ebuchi, and
K Tsukada, and
T Sagara, and
T Kawasaki, and
S Murakami, and
N Kasahara, and
H Kudo, and
R Okamoto
January 1986,
Acta neurochirurgica,
S Sakamoto, and
T Iwama, and
M Ebuchi, and
K Tsukada, and
T Sagara, and
T Kawasaki, and
S Murakami, and
N Kasahara, and
H Kudo, and
R Okamoto
January 1997,
Anticancer research,
S Sakamoto, and
T Iwama, and
M Ebuchi, and
K Tsukada, and
T Sagara, and
T Kawasaki, and
S Murakami, and
N Kasahara, and
H Kudo, and
R Okamoto
January 2022,
European journal of cell biology,
S Sakamoto, and
T Iwama, and
M Ebuchi, and
K Tsukada, and
T Sagara, and
T Kawasaki, and
S Murakami, and
N Kasahara, and
H Kudo, and
R Okamoto
November 1974,
International journal of cancer,
S Sakamoto, and
T Iwama, and
M Ebuchi, and
K Tsukada, and
T Sagara, and
T Kawasaki, and
S Murakami, and
N Kasahara, and
H Kudo, and
R Okamoto
January 1975,
Cold Spring Harbor symposia on quantitative biology,
S Sakamoto, and
T Iwama, and
M Ebuchi, and
K Tsukada, and
T Sagara, and
T Kawasaki, and
S Murakami, and
N Kasahara, and
H Kudo, and
R Okamoto
June 1988,
Nihon Geka Gakkai zasshi,
S Sakamoto, and
T Iwama, and
M Ebuchi, and
K Tsukada, and
T Sagara, and
T Kawasaki, and
S Murakami, and
N Kasahara, and
H Kudo, and
R Okamoto
September 1993,
Nihon Geka Gakkai zasshi,
