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Pertussis toxin, a substance known to inactivate the inhibitory guanine nucleotide regulatory unit of adenylate cyclase, was injected into the lateral cerebral ventricle of rats; intracellular recordings were made from locus coeruleus neurons in brain slices 1-3 days later. Morphine (an opiate agonist) and clonidine (an alpha 2-agonist) produced the expected outward currents (and associated hyperpolarization and inhibition of firing) in controls whereas the effects of both agonists were blocked in animals pretreated with pertussis toxin. These results are consistent with the hypothesis that opiate and alpha 2-agonists may depress the firing of locus coeruleus neurons by inhibiting adenylate cyclase via a guanine nucleotide regulatory protein.
G K Aghajanian, and
Y Y Wang
July 1988,
Neuroscience letters,
G K Aghajanian, and
Y Y Wang
November 1988,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
G K Aghajanian, and
Y Y Wang
November 1992,
Pharmacology, biochemistry, and behavior,
G K Aghajanian, and
Y Y Wang
September 2010,
Neuroscience,
G K Aghajanian, and
Y Y Wang
January 1990,
Acta physiologica Hungarica,
G K Aghajanian, and
Y Y Wang
January 1995,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
G K Aghajanian, and
Y Y Wang
January 2008,
Neuroscience research,
G K Aghajanian, and
Y Y Wang
June 2001,
Journal of neurophysiology,
G K Aghajanian, and
Y Y Wang
December 1998,
Annals of the New York Academy of Sciences,
G K Aghajanian, and
Y Y Wang
November 1985,
Circulation research,
