-transparent.png){kind=logo}
The carcinogenic effects of weekly subcutaneous injections of dimethylnitrosamine (NDMA: 0.05 of the LD50) and diethylstilbestrol (DES: 1.5 mg/kg body wt) or a combination of both carcinogens were studied in 64 Syrian hamsters. There was no additional tumorigenic effect on NDMA-induced liver tumours in hamsters which received DES treatment prior to NDMA treatment. In contrast to the previously reported DES effects, 72% of the DES-treated hamsters unexpectedly developed undifferentiated sarcomas around the interscapular injection site. This finding suggests a local carcinogenicity of DES, which might not be related to its hormonal effects.
Related Publications
H Ernst, and
M Riebe, and
U Mohr
December 1992,
Research communications in chemical pathology and pharmacology,
H Ernst, and
M Riebe, and
U Mohr
November 1984,
Acta pathologica japonica,
H Ernst, and
M Riebe, and
U Mohr
January 1986,
Neuroendocrinology,
H Ernst, and
M Riebe, and
U Mohr
June 1960,
Archives of pathology,
H Ernst, and
M Riebe, and
U Mohr
July 1989,
Carcinogenesis,
H Ernst, and
M Riebe, and
U Mohr
February 1993,
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,
H Ernst, and
M Riebe, and
U Mohr
May 1995,
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,
H Ernst, and
M Riebe, and
U Mohr
April 1979,
Journal of the National Cancer Institute,
H Ernst, and
M Riebe, and
U Mohr
January 1972,
Archiv fur Geschwulstforschung,
H Ernst, and
M Riebe, and
U Mohr
January 1982,
Progress in clinical and biological research,
