The problems involved in the treatment of malignant tumours of the maxillary antrum are described and the need for a disciplined approach emphasised. The overall crude 5-year survival rate for this series of 43 cases was 49%. For the 34 patients suffering from carcinoma the rate was 44%. It is suggested that primary surgery be avoided because in the 23 cases treated by radiotherapy before major surgery the 5-year crude survival rate was 60.8%.