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The antiemetic activity, gastric motor activity, and dopamine receptor effects of metoclopramide, dazopride, and sulpiride were assessed to establish if enhancement of gastric motility or antagonism of central dopamine receptors is the predominant action for drug-induced suppression of cisplatin-induced emesis. Emesis produced in dogs by cisplatin is antagonized by metoclopramide and dazopride. The antiemetic actions of metoclopramide and dazopride are associated with their ability to enhance gastric motor activity. Dazopride, unlike metoclopramide, has minimal dopamine receptor antagonist properties. Sulpiride is a potent dopamine receptor antagonist; however, it had no effect on the stomach and was ineffective in suppressing cisplatin-induced emesis.
R S Alphin, and
A G Proakis, and
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D N Johnson, and
L F Sancilio, and
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Annals of internal medicine,
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D N Johnson, and
L F Sancilio, and
J W Ward
February 1986,
Journal of clinical pharmacology,
R S Alphin, and
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C A Leonard, and
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L F Sancilio, and
J W Ward
January 1979,
Research communications in chemical pathology and pharmacology,
R S Alphin, and
A G Proakis, and
C A Leonard, and
W L Smith, and
W N Dannenburg, and
W J Kinnier, and
D N Johnson, and
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J W Ward
July 1987,
Neuropharmacology,
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W J Kinnier, and
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October 1986,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
R S Alphin, and
A G Proakis, and
C A Leonard, and
W L Smith, and
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L F Sancilio, and
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January 1984,
Cancer chemotherapy and pharmacology,
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W N Dannenburg, and
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May 1987,
Pharmacology & toxicology,
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February 1989,
Cancer,
R S Alphin, and
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July 1984,
Annals of internal medicine,
R S Alphin, and
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W N Dannenburg, and
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L F Sancilio, and
J W Ward
August 1986,
Neuropharmacology,
