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Pregnant rats were intubated with alcohol (3.5 g/kg, twice daily) on gestation days 11-21. Control animals were intubated with an isocaloric sucrose solution and were pair-fed and pair-watered to alcohol-treated dams. At birth, offspring were placed with non-treated surrogate dams. When animals were slightly more than 1 year of age, they were tested for passive avoidance learning, spontaneous alternation and activity. Groups did not differ in passive avoidance learning or spontaneous alteration but animals prenatally exposed to alcohol were more active than controls. Additional studies showed that this increased activity was not affected by testing animals in the presence of environmental stimuli such as objects which could be manipulated, or by odors from mouse shavings from male and female mice.
E L Abel, and
B A Dintcheff
November 1986,
Pharmacology, biochemistry, and behavior,
E L Abel, and
B A Dintcheff
July 1993,
Journal of gerontology,
E L Abel, and
B A Dintcheff
January 1987,
Neurotoxicology and teratology,
E L Abel, and
B A Dintcheff
April 2006,
Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology,
E L Abel, and
B A Dintcheff
June 2011,
Neuropsychology review,
E L Abel, and
B A Dintcheff
January 1988,
Neurotoxicology and teratology,
E L Abel, and
B A Dintcheff
January 2009,
Neurotoxicology and teratology,
E L Abel, and
B A Dintcheff
January 2000,
Neurotoxicology and teratology,
E L Abel, and
B A Dintcheff
January 2000,
Hippocampus,
E L Abel, and
B A Dintcheff
January 1981,
Psychopharmacology,
