BIOMAT Database Logo BIOMAT Database Logo

Comment on "Tacrolimus Drug-Drug Interaction with Nirmatrelvir/Ritonavir (Paxlovid™) Managed with Phenytoin". 2023

Luciana Mello de Oliveira, and Tatiane da Silva Dal Pizzol
Núcleo de Avaliação de Tecnologias em Saúde, Gerência de Ensino e Pesquisa, Grupo Hospitalar Conceição (GEP-GHC), Porto Alegre, Rio Grande do Sul, Brazil. oliveiralm@gmail.com.

UI MeSH Term Description Entries
D010672 Phenytoin An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. Diphenylhydantoin,Fenitoin,Phenhydan,5,5-Diphenylhydantoin,5,5-diphenylimidazolidine-2,4-dione,Antisacer,Difenin,Dihydan,Dilantin,Epamin,Epanutin,Hydantol,Phenytoin Sodium,Sodium Diphenylhydantoinate,Diphenylhydantoinate, Sodium
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016559 Tacrolimus A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Anhydrous Tacrolimus,FK-506,FK506,FR-900506,Prograf,Prograft,Tacrolimus Anhydrous,Anhydrous, Tacrolimus,FK 506,FR 900506,FR900506,Tacrolimus, Anhydrous
D019438 Ritonavir An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. It also inhibits CYTOCHROME P-450 CYP3A. ABT 538,ABT-538,Norvir,ABT538

Related Publications

Luciana Mello de Oliveira, and Tatiane da Silva Dal Pizzol
Tacrolimus Drug-Drug Interaction with Nirmatrelvir/Ritonavir (Paxlovid™) Managed with Phenytoin.
January 2023, Journal of medical toxicology : official journal of the American College of Medical Toxicology,
Luciana Mello de Oliveira, and Tatiane da Silva Dal Pizzol
Response to Comment on "Tacrolimus Drug-Drug Interaction with Nirmatrelvir/Ritonavir (Paxlovid™) Managed with Phenytoin".
July 2023, Journal of medical toxicology : official journal of the American College of Medical Toxicology,
Luciana Mello de Oliveira, and Tatiane da Silva Dal Pizzol
Drug Interaction Between Tacrolimus and Paxlovid (Nirmatrelvir/Ritonavir) in an Adolescent with Inflammatory Bowel Disease.
November 2023, JPGN reports,
Luciana Mello de Oliveira, and Tatiane da Silva Dal Pizzol
Paxlovid (nirmatrelvir/ritonavir).
January 2022, WMJ : official publication of the State Medical Society of Wisconsin,
Luciana Mello de Oliveira, and Tatiane da Silva Dal Pizzol
Treatment of acute tacrolimus toxicity with phenytoin after Paxlovid (nirmatrelvir/ritonavir) administration in a kidney transplant recipient.
November 2022, Kidney research and clinical practice,
Luciana Mello de Oliveira, and Tatiane da Silva Dal Pizzol
Phenytoin enzyme induction for management of supratherapeutic tacrolimus levels due to drug-drug interaction with nirmatrelvir/ritonavir: Case series and discussion.
February 2024, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists,
Luciana Mello de Oliveira, and Tatiane da Silva Dal Pizzol
Nirmatrelvir/ritonavir (Paxlovid®): French pharmacovigilance survey 2022.
January 2023, Therapie,
Luciana Mello de Oliveira, and Tatiane da Silva Dal Pizzol
Generalized use of Nirmatrelvir plus ritonavir (Paxlovid): Raising concerns.
February 2023, Enfermedades infecciosas y microbiologia clinica (English ed.),
Luciana Mello de Oliveira, and Tatiane da Silva Dal Pizzol
[Nirmatrelvir/ritonavir (Paxlovid®), a treatment for Covid-19].
June 2022, Actualites pharmaceutiques,
Luciana Mello de Oliveira, and Tatiane da Silva Dal Pizzol
Generalized use of Nirmatrelvir plus ritonavir (Paxlovid): Raising concerns.
February 2023, Enfermedades infecciosas y microbiologia clinica,
Copied contents to your clipboard!