Biomaterial Database

Kinetic models of induction: I. Persistence of the inducing substance. 1986

F P Abramson

A kinetic model for induction is presented which includes the pharmacokinetics of the inducing agent. When simulations based on this model are carried out, they demonstrate situations where the observed rate constant governing the change from the basal to the induced state, or from the induced to the basal state, differs substantially from the true turnover rate constant. This arises from the confounding influences of the accumulation or persistence of either the inducing agent itself or some intermediary metabolic process. Depending on the relationships between the kinetic constants, there are four experimental subsets which require various interpretative schemes to obtain a correct estimate of the turnover rate constant. These interpretive schemes point out the necessity of measuring the pharmacokinetics of the inducer in all experiments.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D004790	Enzyme Induction	An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.	Induction, Enzyme
D006207	Half-Life	The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.	Halflife,Half Life,Half-Lifes,Halflifes
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man