Biomaterial Database

Kinetic models of induction: II. Decreased turnover of a product or its precursor. 1986

F P Abramson

Reduction of the turnover rate constant for a substance or its metabolic precursor is a mechanism for induction which differs markedly in its kinetic characteristics from induction resulting from a direct stimulation of synthesis. The unique aspect of induction following inhibited turnover is that the time course of recovery from the induced to the basal state is more rapid than the time course for induction itself. A general set of kinetic equations is presented here which represents the complete chain of events for such an induction; namely the kinetics of the inducer, the kinetics of a synthesis precursor to the induced product, and the kinetics of the induced product itself. These equations have been used to simulate examples of this type of induction and resemble induction experiments from the literature.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D004790	Enzyme Induction	An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.	Induction, Enzyme
D006207	Half-Life	The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.	Halflife,Half Life,Half-Lifes,Halflifes