Biomaterial Database

Differences in acquisition of discrete lever-press and shuttle avoidance responses in 6 strains of mice. 1986

H Kuribara, and S Tadokoro

Characteristics of the acquisition processes of discrete lever-press and shuttle avoidance responses (intertrial interval = 25 sec, warning duration = 5 sec with an escape contingency, and 1 session = 1 hr training/day) as well as those of the ambulatory activity were investigated in 6 strains of mice (dd, ICR, BALB/c, C57BL/6, C3H/He and DBA/2). In the lever-press avoidance situation, the dd, BALB/c and DBA/2 strains demonstrated a good avoidance response, showing average avoidance rates of higher than 80% within 10-15 sessions of the training. The C3H/He also demonstrated a good avoidance response, though 20 sessions or more of the training were required to attain to the level. The ICR and C57BL/6 strains demonstrated a poorer avoidance response than the other 4 strains, and achieved average avoidance rates of 30-40%. The dd, BALB/c, C3H/He and DBA/2 strains also demonstrated a good shuttle avoidance response when they were trained in an experimental box of 50 cm in width. In contrast, the ICR and C57BL/6 strains demonstrated an extremely poor avoidance response in this situation, showing an average avoidance rate of less than 10%. However, when the dd, ICR and C57BL/6 strains were trained in a shuttle box of 30 cm in width, they rapidly acquired the avoidance response, and the average avoidance rates finally achieved were much higher than those of the mice trained in the shuttle box of 50 cm in width. In particular, the C57BL/6 strain exhibited the best avoidance response among the 3 strains. The ambulatory activity of the C57BL/6 strain was less than those of the other 5 strains.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D003213	Conditioning, Psychological	Simple form of learning involving the formation, strengthening, or weakening of an association between a stimulus and a response.	Conditioning, Psychology,Psychological Conditioning,Social Learning Theory,Social Learning Theories,Theory, Social Learning
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001362	Avoidance Learning	A response to a cue that is instrumental in avoiding a noxious experience.	Aversion Behavior,Aversion Learning,Aversive Behavior,Aversive Learning,Avoidance Behavior,Aversion Behaviors,Aversive Behaviors,Avoidance Behaviors,Behavior, Aversion,Behavior, Aversive,Behavior, Avoidance,Behaviors, Aversion,Behaviors, Aversive,Behaviors, Avoidance,Learning, Aversion,Learning, Aversive,Learning, Avoidance
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus