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Reversal of Right Ventricular Remodeling After Correction of Pulmonary Regurgitation in Tetralogy of Fallot. 2023
Bjorn Cools, and
Chandan Kadur Nagaraju, and
Katrien Vandendriessche, and
Joeri van Puyvelde, and
Mohamad Youness, and
H Llewelyn Roderick, and
Marc Gewillig, and
Karin Sipido, and
Piet Claus, and
Filip Rega
Department of Pediatric and Congenital Cardiology, University Hospitals Leuven, Leuven, Belgium.
In the sheep model with pathophysiologic changes similar to patients with repaired TOF, severe PR leads to fibrotic changes in the RV. Pulmonary valve replacement reverses these fibrotic changes. Early valve replacement led to a quick RV recovery, and in time there was no difference in outcome between early and late valve replacement. These data support the benefit of valve replacement for RV function and suggest that there is a margin in the timing of the surgery. The fibrotic changes correlated well with the circulating biomarker PICP, which can have an added value in the clinical follow-up of patients with repaired TOF.
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