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The effects of morphine administered to pregnant Sprague-Dawley rats on the schedule-controlled behavior of the offspring were examined. It was observed that both male and female adult rats exposed prenatally to morphine were tolerant to the disruptive effects of morphine on fixed-interval responding compared to age-matched controls. These morphine-treated rats, however, were neither tolerant nor supersensitive to the disruptive effects of the catecholaminergic agonist, amphetamine, and did not exhibit any alteration in their steady state levels of central monoamines. These observations are discussed in relation to the effects of prenatal morphine exposure on unconditioned behaviors.
G C Wagner, and
M F Jarvis, and
D S Gottesfeld, and
M Giorlando, and
J Rabii
April 1998,
Pharmacology, biochemistry, and behavior,
G C Wagner, and
M F Jarvis, and
D S Gottesfeld, and
M Giorlando, and
J Rabii
July 1984,
Pharmacology, biochemistry, and behavior,
G C Wagner, and
M F Jarvis, and
D S Gottesfeld, and
M Giorlando, and
J Rabii
July 1964,
Psychopharmacologia,
G C Wagner, and
M F Jarvis, and
D S Gottesfeld, and
M Giorlando, and
J Rabii
January 1979,
Neurobehavioral toxicology,
G C Wagner, and
M F Jarvis, and
D S Gottesfeld, and
M Giorlando, and
J Rabii
May 1982,
Life sciences,
G C Wagner, and
M F Jarvis, and
D S Gottesfeld, and
M Giorlando, and
J Rabii
March 1977,
Psychopharmacology,
G C Wagner, and
M F Jarvis, and
D S Gottesfeld, and
M Giorlando, and
J Rabii
May 1997,
Psychopharmacology,
G C Wagner, and
M F Jarvis, and
D S Gottesfeld, and
M Giorlando, and
J Rabii
August 1992,
Brain research,
G C Wagner, and
M F Jarvis, and
D S Gottesfeld, and
M Giorlando, and
J Rabii
March 1972,
Research communications in chemical pathology and pharmacology,
G C Wagner, and
M F Jarvis, and
D S Gottesfeld, and
M Giorlando, and
J Rabii
June 1992,
Behavioural pharmacology,
